Document Detail

Immunomodulatory potential of partially hydrolyzed ß-lactoglobulin and large synthetic peptides.
MedLine Citation:
PMID:  23043375     Owner:  NLM     Status:  Publisher    
The immunomodulatory potential of fragments derived from the cow's milk allergen bovine ß-lactoglobulin (BLG) was assessed in a mouse model of oral tolerance (OT). Native BLG (nBLG) and chemically denatured BLG (lacking S-S bridges, dBLG), products resulting from their hydrolysis using cyanogen bromide (CNBr) and some synthetic peptides were produced and precisely characterized. CNBr-hydrolysates correspond to pools of peptides of various sizes that are still associated by S-S bridges when derived from nBLG. nBLG, dBLG and CNBr hydrolysate of nBLG efficiently prevented further sensitization. CNBr hydrolysate of dBLG was less efficient suggesting that the association by S-S bridges of peptides increased their immunomodulatory potential. Conversely, synthetic peptides were inefficient even if covering 50% of the BLG sequence demonstrating that the immunomodulatory potential requires the presence of all the derived fragments of BLG and further supporting the use of partially hydrolysed milk proteins to favor OT induction in infants with a risk of atopy.
K Adel-Patient; S Nutten; H Bernard; R Fritsché; S Ah-Leung; N Meziti; G Prioult; A Mercenier; J-M Wal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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