Document Detail

Immunomodulatory effects of dietary intake of chitin on gilthead seabream (Sparus aurata L.) innate immune system.
MedLine Citation:
PMID:  11417718     Owner:  NLM     Status:  MEDLINE    
To determine the effects of chitin (poly [1-->4]-beta-N-acetyl-D-glucosamine) on the innate immune response of gilthead seabream (Sparus aurata L.), fish were fed diets containing 0 mg (control), 25, 50 or 100 mg kg(-1) chitin for 2, 4 and 6 weeks. Lysozyme and natural haemolytic complement activities, together with head-kidney leucocyte respiratory burst, phagocytic and cytotoxic activities, were studied at each of the assayed times. Lysozyme activity was unaffected by the administration of chitin. The innate humoral and cellular immune response activities assayed were enhanced by the dietary intake of chitin, each increasing at a different time: natural haemolytic complement activity and cytotoxic activity after 2 weeks of treatment, respiratory burst activity from 4 weeks and phagocytic activity after 6 weeks, although, unlike the other activities, no statistically significant differences were observed in the first. The results indicate that chitin increases the activity of the seabream innate immune system, and its use as an immunostimulant is discussed, especially with regards to the protective role.
M A Esteban; A Cuesta; J Ortuño; J Meseguer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fish & shellfish immunology     Volume:  11     ISSN:  1050-4648     ISO Abbreviation:  Fish Shellfish Immunol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-21     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505220     Medline TA:  Fish Shellfish Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-15     Citation Subset:  IM    
Department of Cell Biology, Faculty of Biology, University of Murcia, Spain.
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MeSH Terms
Chitin / administration & dosage,  pharmacology*
Complement System Proteins / drug effects
Cytotoxicity, Immunologic / drug effects
Dose-Response Relationship, Drug
Leukocytes / drug effects*,  immunology
Muramidase / blood,  drug effects
Phagocytosis / drug effects
Random Allocation
Respiratory Burst / drug effects
Sea Bream / growth & development,  immunology*
Reg. No./Substance:
1398-61-4/Chitin; 9007-36-7/Complement System Proteins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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