| Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. | |
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MedLine Citation:
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PMID: 17499975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antidepressants have an antiproliferative effect in some cell lines. Depression may be associated with activation of some pro-inflammatory cytokines. Therefore, we evaluated the ex-vivo immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) in T cells. We found that the SSRIs, paroxetine and sertraline decreased T-cell viability with IC50 around 10 microM. The inhibition obtained with exposure to the SSRIs was more pronounced than that achieved with dexamethasone. Moreover, these SSRIs inhibit the secretion of the TH1 factor-tumor necrosis factor(TNF)alpha from the cells. On the molecular level, the SSRIs suppressed signal transducer and activator of transcription 3 (Stat3) and cyclooxygenase(Cox)2 protein expression. The inhibitory effects were accompanied by alterations in gene expression as assessed in the gene array. These findings reveal an immunomodulatory effect of the SSRIs paroxetine and sertraline in human T cells. The clinical implications of our findings merit further investigation. |
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Authors:
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Michal Taler; Irit Gil-Ad; Liat Lomnitski; Inna Korov; Ehud Baharav; Meytal Bar; Amichay Zolokov; Abraham Weizman |
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Publication Detail:
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Type: Journal Article Date: 2007-05-14 |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 17 ISSN: 0924-977X ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-10-23 Completed Date: 2008-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 774-80 Citation Subset: IM |
Affiliation:
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Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel. michalt@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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pharmacology Antidepressive Agents / pharmacology Cell Survival / drug effects Cells, Cultured Cyclooxygenase 2 / genetics, metabolism Cytokines / metabolism* Dexamethasone / pharmacology Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay / methods Gene Expression / drug effects* Gene Expression Regulation / drug effects Humans Inhibitory Concentration 50 Oligonucleotide Array Sequence Analysis / methods Paroxetine / pharmacology STAT3 Transcription Factor / genetics, metabolism Serotonin Uptake Inhibitors / pharmacology* Sertraline / pharmacology T-Lymphocytes / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antidepressive Agents; 0/Cytokines; 0/STAT3 Transcription Factor; 0/STAT3 protein, human; 0/Serotonin Uptake Inhibitors; 50-02-2/Dexamethasone; 61869-08-7/Paroxetine; 79617-96-2/Sertraline; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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