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Immunomodulatory effect of a proanthocyanidin-rich extract from Pinus radiata bark by dosing period in chickens.
MedLine Citation:
PMID:  23300300     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We evaluated the immunomodulatory effects of a proanthocyanidin-rich extract (PAE) from Pinus radiata bark in Korean native chickens. In experiment 1, proliferation of peripheral blood mononuclear cells was significantly enhanced in chickens administered 1.25, 2.5, 5, and 10 mg/kg of PAE for 2 wk once daily by oral gavage compared with no administration of PAE in vitro. Proliferation of splenocyte and thymocyte cells was also significantly enhanced in chickens administered 1.25, 2.5, 5, and 10 mg/kg of PAE for 5 wk. In experiment 2, proliferation of peripheral blood mononuclear cells, splenocytes, and thymocytes in chickens administered PAE for 6 wk was continuously higher than that in other groups. Additionally, increasing cell populations for which CD4(+)CD8(-)(Th cells) and Bu-1(+) (B cells) protein was expressed on the cell surface were significantly different after 4 wk of PAE administration in chickens. Thus, the immunomodulatory effects of a PAE from P. radiata bark differed by dosing period in chickens.
Authors:
In-Jae Park; Se-Yeoun Cha; Min Kang; Hyung-Kwan Jang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Poultry science     Volume:  92     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Affiliation:
Departments of Infectious Diseases and Avian Diseases, College of Veterinary Medicine and Korea Zoonosis Research Institute, Chonbuk National University, Chonbuk, 561-756, Korea.
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