| Immunomodulatory effect of pentoxifylline in suppressing experimental autoimmune myocarditis. | |
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MedLine Citation:
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PMID: 12030348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although a recent clinical study reported the beneficial effects of pentoxifylline (PTX), a phosphodiesterase inhibitor, on both symptoms and cardiac function in dilated cardiomyopathy (DCM), the precise mechanism of the drug has not been delineated. This study examined the efficacy of PTX in the treatment of experimental autoimmune myocarditis (EAM), as a model of the autoimmune mechanism involved in DCM. Oral PTX, or saline as control, was administered to Lewis rats at 150mg/kg body weight per day bid daily from 5 days before immunization with cardiac myosin until death on Day 21. Histological examination of the hearts showed PTX significantly reduced the severity of EAM. mRNA expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-4, IL-6, and IL-10 was significantly reduced in peripheral blood mononuclear cells, but expression of IL-4 and IL-6 was upregulated in heart tissue. PTX in vitro could suppress T cell proliferation and inhibit TNF-alpha and interferon-gamma production. In conclusion, the immunomodulatory effects of PTX had a significant therapeutic result in EAM. This is the first report to describe such an effect of PTX in a specific animal model for DCM. |
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Authors:
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Hitoshi Takehana; Takayuki Inomata; Hiroe Niwano; Mototsugu Nishii; Chieko Matsuda; Ken Kohno; Yoji Machida; Tohru Izumi |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 66 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-27 Completed Date: 2002-11-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 499-504 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. takehana@med.kitasato-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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therapeutic use* Animals Autoimmune Diseases / drug therapy*, immunology, metabolism, pathology Cell Division / drug effects Cytokines / biosynthesis Female Myocarditis / drug therapy*, immunology, metabolism, pathology Myocardium / metabolism Pentoxifylline / therapeutic use* Rats Rats, Inbred Lew Severity of Illness Index T-Lymphocytes / immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Cytokines; 6493-05-6/Pentoxifylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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