Document Detail


Immunomodulatory constituents of human milk change in response to infant bronchiolitis.
MedLine Citation:
PMID:  17680907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although epidemiological evidence is generally supportive of a causal association between respiratory syncytial virus (RSV) bronchiolitis during infancy and the development of persistent wheeze/asthma, if not allergy, the mechanism by which this occurs and an explanation for why all children do not succumb remains to be elucidated. Breast feeding has been found to confer a protective effect against respiratory infections such as RSV bronchiolitis and allergy; however, again there is little direct evidence and no clear mechanism. In this study, we examined whether human milk immunomodulatory factors (cells, cytokines) change in response to clinically diagnosed, severe bronchiolitis in the recipient breast-fed infant. We examined milk from 36 breast feeding mothers of infants hospitalized with bronchiolitis and compared them with milk from 63 mothers of postpartum age-matched healthy controls. Milks from mothers of infants hospitalized with bronchiolitis had significantly greater numbers of viable cells when compared with the milks obtained from mothers of healthy infants (1.3 +/- 0.4 vs. 0.3 +/- 0.03 x 10(6) cells/ml, mean +/- s.e.m.; p < or = 0.001). Further, the cells obtained from the mothers of infants hospitalized with bronchiolitis were found to produce a skewed cytokine profile ex vivo in response to stimulation by live RSV but not when cultured with a non-specific mitogen (concanavalin A). This study provides preliminary evidence for an immunological link between mothers and their breast-fed infants during severe respiratory infections as well as a possible contributing factor to the development of persistent wheeze in these infants.
Authors:
Dani-Louise Bryan; Prue H Hart; Kevin D Forsyth; Robert A Gibson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  18     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-07     Completed Date:  2007-10-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  495-502     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Child Health, Flinders University, South Australia, Australia. dani.bryan@flinders.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Breast Feeding*
Bronchiolitis, Viral / immunology*,  metabolism,  virology
Case-Control Studies
Cell Count
Cells, Cultured
Chemokine CCL5 / metabolism
Cytokines / metabolism*
Female
Humans
Immunologic Factors / metabolism*
Infant
Infant, Newborn
Infant, Newborn, Diseases / immunology*,  metabolism,  virology
Interferon-gamma / metabolism
Interleukin-10 / metabolism
Interleukin-2 / metabolism
Interleukin-4 / metabolism
Milk, Human / cytology,  immunology*,  metabolism
Respiratory Sounds / immunology
Respiratory Syncytial Virus Infections / complications*,  immunology,  metabolism,  virology
Respiratory Syncytial Virus, Human / immunology*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Chemokine CCL5; 0/Cytokines; 0/IL10 protein, human; 0/IL4 protein, human; 0/Immunologic Factors; 0/Interleukin-2; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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