Document Detail


Immunomodulatory and clinical effects of Viscum album (Iscador M and Iscador P) in children with recurrent respiratory infections as a result of the Chernobyl nuclear accident.
MedLine Citation:
PMID:  11317168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ninety-two children 5 to 14 years of age living in areas exposed to the radioactive fallout from Chernobyl with recurrent respiratory infections (RRIs) were treated after randomization with either Viscum album praeparatum mali or pini (Iscador M or P). The dosage was two subcutaneous injections a week for 5 weeks with individual doses of 0.001 mg to 1.0 mg. Both Viscum album preparations were effective in significantly reducing clinical symptoms. One year after a single treatment course, the frequency of RRI relapses decreased by 78% and 73%, respectively. Immunomodulatory effects were assessed by investigation of lymphocyte subsets, natural killer (NK) cell activity, phagocytic and oxidative activity of polymorphonuclear leukocytes, and antiviral activity of serum before and 1 week after treatment. Viscum album therapy resulted in normalization of initial immune indices either below or above the normal ranges. High levels of antiviral activity before treatment were significantly decreased by Viscum album mali. Viscum album treatment should be studied further in children with RRI.
Authors:
V P Chernyshov; P Heusser; L I Omelchenko; L I Chernyshova; M A Vodyanik; E V Vykhovanets; L V Galazyuk; T V Pochinok; N V Gaiday; M E Gumenyuk; G M Zelinsky; H Schaefermeyer; G Schaefermeyer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of therapeutics     Volume:  7     ISSN:  1075-2765     ISO Abbreviation:  Am J Ther     Publication Date:  2000 May 
Date Detail:
Created Date:  2001-04-24     Completed Date:  2001-05-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  195-203     Citation Subset:  IM    
Affiliation:
Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences, Kiev 1st Clinical Center, Arlesheim, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antineoplastic Agents, Phytogenic / immunology,  pharmacology*
Child
Female
Humans
Immunity, Cellular / drug effects
Immunocompromised Host*
Injections, Subcutaneous
Male
Mistletoe
Plant Extracts / immunology,  pharmacology*
Plant Proteins*
Plants, Medicinal
Power Plants
Radioactive Fallout / adverse effects*
Radioactive Hazard Release*
Recurrence
Respiratory Tract Infections / drug therapy*,  immunology
Ukraine
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/Plant Proteins; 0/Radioactive Fallout; 0/viscum album peptide

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