| Immunomodulatory cell therapy in sepsis: have we learnt lessons from the past? | |
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MedLine Citation:
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PMID: 20954877 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Sepsis still constitutes a public health challenge worldwide since its incidence constantly increases over time but its related mortality remains more or less constant. There is thus an unquestionable and urgent need to develop innovative and efficacious therapies for the treatment of this deadly disease. In this study, the authors propose that injection of mesenchymal stem cells rescues mice from death after septic shock owing to their potent immunosuppressive and anti-inflammatory properties. The authors conclude that immunomodulatory cell therapy may represent an effective treatment for sepsis. While the potential therapeutic value of these cells is not to be challenged, considering the present lack of convincing data about mesenchymal stem cell use in sepsis, we do not believe that they constitute the next topical clinical trial in the field. Rather, recent evidence indicates that most septic patients actually present with profound immune alterations suggesting that anti-inflammatory approaches could deleteriously amplify this state. Therefore, in this article, we propose hypotheses explaining why the future of clinical trials in sepsis immunology will likely rely on stimulating immune functions for rebalancing immune homeostasis. |
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Authors:
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Guillaume Monneret; Fabienne Venet |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Expert review of anti-infective therapy Volume: 8 ISSN: 1744-8336 ISO Abbreviation: Expert Rev Anti Infect Ther Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181284 Medline TA: Expert Rev Anti Infect Ther Country: England |
Other Details:
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Languages: eng Pagination: 1109-12 Citation Subset: - |
Affiliation:
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Cellular Immunology Laboratory, Hôpital E. Herriot, Hospices Civils de Lyon, Pavillon E, 5 place d'Arsonval, 69437 Lyon Cedex 03, France. guillaume.monneret@chu-lyon.fr |
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Comment On:
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Am J Respir Crit Care Med. 2010 Oct 15;182(8):1047-57
[PMID:
20558630
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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