Document Detail


Immunomodulatory and antitumor activity of Biophytum sensitivum extract.
MedLine Citation:
PMID:  17477767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An alcoholic extract of Biophytum sensitivum was studied for its immunomodulatory and antitumor activity. The extract was 100% toxic at a concentration of 0.5 mg/ml to Dalton's lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC) cells. B. sensitivum extract was also found to be cytotoxic towards L929 cells in culture at a concentration of 0.1 mg/ml. Administration of B. sensitivum extract (500 microg/dose/animal) could inhibit the solid tumor development in mice induced with DLA cells and increase the lifespan of mice bearing Ehrlich ascites carcinoma tumors by 93.3%. B. sensitivum treatment significantly (p<0.001) reduced the tumor cell glutathione (GSH) levels as well as serum gamma glutamyl transpeptidase (GGT) and nitric oxide (NO) levels in ascites tumor bearing animals. The total WBC count was also increased to 14,087 cells/mm(3) on the 12th day in BALB/c mice. The number of plaque forming cells also enhanced significantly (p<0.001), and bone marrow cellularity and beta-esterase positive cells were also increased by the administration of B. sensitivum extract.
Authors:
C Guruvayoorappan; Girija Kuttan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of cancer prevention : APJCP     Volume:  8     ISSN:  1513-7368     ISO Abbreviation:  Asian Pac. J. Cancer Prev.     Publication Date:    2007 Jan-Mar
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130625     Medline TA:  Asian Pac J Cancer Prev     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Affiliation:
Department of Immunology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680 555, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / therapeutic use*
Ascites / drug therapy*,  immunology
Carcinoma, Ehrlich Tumor / drug therapy*,  immunology
Erythrocytes / drug effects
Glutathione / metabolism
Lymphoma / drug therapy*,  immunology
Mice
Mice, Inbred BALB C
Nitric Oxide / blood
Phytotherapy*
Plant Extracts / therapeutic use*
Plants, Medicinal / chemistry*
Sheep
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 10102-43-9/Nitric Oxide; 70-18-8/Glutathione

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