Document Detail

Immunomodulatory activity of methanolic extract of Murraya koenigii (L) Spreng. leaves.
MedLine Citation:
PMID:  18807753     Owner:  NLM     Status:  MEDLINE    
Immunomodulatory activity of methanolic extract of M. koenigii leaves was evaluated on humoral and cell mediated immune response to ovalbumin, phagocytic activity by carbon clearance test, nitric oxide (NO) release from murine peritoneal macrophages and cyclophosphamide induced myelosuppression. Significant increase in the NO production by mouse peritoneal macrophages was detected in culture supernatants indicated increased phagocytic activity of macrophages. The extract showed significant increase in phagocytic index by rapid removal of carbon particles from blood stream. The extract also increased the antibody titre against the ovalbumin and protection towards the cyclophosphamide induced myelosuppression. However, the extract did not show any significant increase in delayed type hypersensitivity reaction which indicated the inability of the extract to stimulate T cells. Present study thus reveals that the extract holds promise as immunomodulatory agent, which acts by stimulating humoral immunity and phagocytic function.
Abhishek S Shah; Alok S Wakade; Archana R Juvekar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  46     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  505-9     Citation Subset:  IM    
Department of Pharmaceutical Sciences and Technology, Mumbai University Institute of Chemical Technology Nathalal Parikh Marg, Matunga, Mumbai 400 019, India.
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MeSH Terms
Cells, Cultured
Immunity / drug effects*,  immunology
Macrophages / drug effects,  immunology,  metabolism
Murraya / chemistry*
Nitrites / metabolism
Phagocytes / drug effects
Plant Extracts / chemistry*,  pharmacology*
Plant Leaves / chemistry*
Reg. No./Substance:
0/Nitrites; 0/Plant Extracts; 67-56-1/Methanol

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