| Immunomodulatory activity of methanolic extract of Murraya koenigii (L) Spreng. leaves. | |
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MedLine Citation:
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PMID: 18807753 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunomodulatory activity of methanolic extract of M. koenigii leaves was evaluated on humoral and cell mediated immune response to ovalbumin, phagocytic activity by carbon clearance test, nitric oxide (NO) release from murine peritoneal macrophages and cyclophosphamide induced myelosuppression. Significant increase in the NO production by mouse peritoneal macrophages was detected in culture supernatants indicated increased phagocytic activity of macrophages. The extract showed significant increase in phagocytic index by rapid removal of carbon particles from blood stream. The extract also increased the antibody titre against the ovalbumin and protection towards the cyclophosphamide induced myelosuppression. However, the extract did not show any significant increase in delayed type hypersensitivity reaction which indicated the inability of the extract to stimulate T cells. Present study thus reveals that the extract holds promise as immunomodulatory agent, which acts by stimulating humoral immunity and phagocytic function. |
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Authors:
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Abhishek S Shah; Alok S Wakade; Archana R Juvekar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of experimental biology Volume: 46 ISSN: 0019-5189 ISO Abbreviation: Indian J. Exp. Biol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2009-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0233411 Medline TA: Indian J Exp Biol Country: India |
Other Details:
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Languages: eng Pagination: 505-9 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences and Technology, Mumbai University Institute of Chemical Technology Nathalal Parikh Marg, Matunga, Mumbai 400 019, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Immunity / drug effects*, immunology Macrophages / drug effects, immunology, metabolism Methanol* Mice Murraya / chemistry* Nitrites / metabolism Phagocytes / drug effects Plant Extracts / chemistry*, pharmacology* Plant Leaves / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Nitrites; 0/Plant Extracts; 67-56-1/Methanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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