| Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. | |
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MedLine Citation:
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PMID: 12898413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of Plantago spp. especially P. major has long been used in the treatment of diseases such as infection, inflammation and cancer. In this study, we evaluated the immunomodulatory activities of five chemical classes of pure compounds obtained from the Plantago genus on human peripheral blood mononuclear cells (PBMC). Studies were conducted on lymphocyte transformation by BrdU immunoassay and secretion of interferon-gamma (IFN-gamma) using an ELISA assay. Results showed that the water-soluble compounds, namely aucubin, chlorogenic acid, ferulic acid, p-coumaric acid and vanillic acid, enhanced the activity of human lymphocyte proliferation and secretion of IFN-gamma. Among the water-insoluble compounds, with the exception of luteolin, both baicalein and baicalin showed an enhancement of the human PBMC. Although oleanolic acid and ursolic acid of the triterpenoids did not significantly affect the proliferation of PBMC, they exhibited a strong stimulation of IFN-gamma secretion. Linalool, a monoterpenoid, showed a similar immunomodulatory activity as the triterpenoids. The present study concludes that the tested compounds, which possess immunostimulating activities, may contribute to the traditional claims of Plantago-based natural products used in treating cancers and infectious diseases. |
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Authors:
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Lien-Chai Chiang; Lean Teik Ng; Wen Chiang; Mei-Yin Chang; Chun-Ching Lin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Planta medica Volume: 69 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-08-04 Completed Date: 2003-10-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 600-4 Citation Subset: IM |
Affiliation:
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Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Cells, Cultured Flavonoids / pharmacology* Humans Iridoids / pharmacology* Leukocytes, Mononuclear Monoterpenes / pharmacology* Phenols / pharmacology* Plantago / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Flavonoids; 0/Iridoids; 0/Monoterpenes; 0/Phenols |
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