Document Detail


Immunomodulative effects of aflatoxins and selenium on human natural killer cells.
MedLine Citation:
PMID:  11474740     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possible immunomodulative effects of aflatoxin B1 and selenium (as sodium selenite) at concentrations lower than 5.10(-11) M or 0.05ppb and 10(-5) M, respectively on natural killer (NK) cells from healthy volunteers were evaluated by a 51Cr release natural killer assay. Aflatoxin B1 and selenium separately had an immunosuppressive effect on NK cell activity. When they were studied in combination, they caused a statistically significant increase of the cytotoxic activity of NK cells in the presence of the lowest concentrations of aflatoxin B1 (0.005ppb) and of sodium selenite (10(-8)M).
Authors:
G Methenitou; C Maravelias; S Athanaselis; A Dona; A Koutselinis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  43     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-4     Citation Subset:  IM    
Affiliation:
Department of Forensic Medicine and Toxicology, School of Medicine, University of Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology*
Aflatoxins / pharmacology*
Cells, Cultured
Chromium Radioisotopes / metabolism
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic / drug effects
Dose-Response Relationship, Drug
Drug Combinations
Humans
Killer Cells, Natural / drug effects*,  immunology
Selenium / pharmacology*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Aflatoxins; 0/Chromium Radioisotopes; 0/Drug Combinations; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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