Document Detail

Immunomodulations induced in rats by exercise on a treadmill.
MedLine Citation:
PMID:  2272984     Owner:  NLM     Status:  MEDLINE    
Various regimens of treadmill exercise (0% slope) were used with rats: 60 min at 15 m/min (T-15), 180 min at 10 m/min (T-10), and 60 min/day at 15 m/min for 6 consecutive days (T-15-6). Exercise resulted in 1) decreases in the absolute number of mononuclear spleen cells in T-10 rats, 2) significant increases in in vitro splenic T-cell blastogenesis in response to phytohemagglutinin in T-10 rats, and 3) significant decreases in T-cell blastogenesis in T-15-6 rats. T-15-6 rats were given aminoglutethimide per os before exercise sessions to study the role of corticosteroids in the alteration of splenic T-cell blastogenesis. Aminoglutethimide significantly increased the T-cell blastogenesis in these T-15-6 rats compared with those not given aminoglutethimide, whereas it had no effect on immune parameters of sedentary rats. These results show that immunomodulations in the rat depend on the treadmill exercise regimen employed. If the mechanisms of the immunomodulation induced by isolated exercise of long duration are not elucidated, these data suggest that corticosteroids are involved in the alteration in T-cell blastogenesis induced by chronic muscular exercise.
A Ferry; B L Weill; M Rieu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  69     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1912-5     Citation Subset:  IM    
Laboratoire de Physiologie des Adaptations, UFR Cochin-Port Royal, Université Paris V, France.
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MeSH Terms
Aminoglutethimide / pharmacology
Cell Count
Immune System / physiology*
Leukocytes, Mononuclear / cytology
Lymphocyte Activation
Motor Activity / physiology*
Phytohemagglutinins / diagnostic use
Spleen / cytology,  drug effects
Time Factors
Reg. No./Substance:
0/Phytohemagglutinins; 125-84-8/Aminoglutethimide

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