Document Detail


Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.
MedLine Citation:
PMID:  23328974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.
Authors:
Amanda L Garner; Jing Yu; Anjali K Struss; Gunnar F Kaufmann; Vladimir V Kravchenko; Kim D Janda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-08-14     Revised Date:  2014-02-23    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1515-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
4-Butyrolactone / analogs & derivatives*,  chemical synthesis,  chemistry,  metabolism
Animals
Bone Marrow Cells / cytology
Endoplasmic Reticulum Stress
Homoserine / analogs & derivatives*,  chemical synthesis,  chemistry,  metabolism
Immunomodulation
Macrophages / immunology,  metabolism
Mice
NF-kappa B / metabolism
Oxidation-Reduction
Poly(ADP-ribose) Polymerases / metabolism
Pseudomonas aeruginosa / physiology
Quorum Sensing / physiology*
Grant Support
ID/Acronym/Agency:
AI077644/AI/NIAID NIH HHS; AI079503/AI/NIAID NIH HHS; AI085324/AI/NIAID NIH HHS; AI094348/AI/NIAID NIH HHS; DE018452/DE/NIDCR NIH HHS; R01 AI077644/AI/NIAID NIH HHS; R21 AI079503/AI/NIAID NIH HHS; R21 AI085324/AI/NIAID NIH HHS; R56 AI094348/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/N-(3-oxododecanoyl)homoserine lactone; 0/NF-kappa B; 1192-20-7/homoserine lactone; 6KA95X0IVO/Homoserine; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; OL659KIY4X/4-Butyrolactone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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