| Immunomodulation and postpartum relapses in patients with multiple sclerosis. | |
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MedLine Citation:
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PMID: 21180639 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Multiple sclerosis (MS) mainly affects young women during a life period with desire for children. Relapse rate decreases during pregnancy and rises after delivery. Therefore, studies on satisfactory postpartum relapse prevention and its efficacy are essential. Previous smaller and uncontrolled studies suggested that intravenous immunoglobulin (IVIG) administration reduced the relapse rate following delivery. The objective of our observational study was to compare the efficacy of IVIG application, treatment with other immunomodulatory compounds or no treatment at all on the postpartal relapse rate in female MS patients from our pregnancy database. One hundred and twenty four pregnancies were followed in a partly prospective design. Relapse rate was reduced during pregnancy (p50.001) and increased during the initial 3 months after delivery in all MS patients (p50.001). The relapse rate reduction showed only a trend in favour of the IVIG-treated women, probably due to the small number of patients. However, analysing the expected number of relapses, IVIG treated patients had significantly less relapses postpartum than the untreated control group matched for disease activity before and during pregnancy (χ(2), p= 0.013). The results suggest that IVIG could be an option to prevent postpartum relapse of MS. |
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Authors:
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Kerstin Hellwig; Christian Beste; Sebastian Schimrigk; Andrew Chan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic advances in neurological disorders Volume: 2 ISSN: 1756-2864 ISO Abbreviation: Ther Adv Neurol Disord Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101480242 Medline TA: Ther Adv Neurol Disord Country: England |
Other Details:
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Languages: eng Pagination: 7-11 Citation Subset: - |
Affiliation:
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Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany k.hellwig@klinikum-bochum.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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