| Immunomodulation, part II: granulocyte colony-stimulating factors. | |
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MedLine Citation:
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PMID: 16514867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although rhG-CSF and rhGM-CSF appear to have no adverse side effects, their usefulness in treating and preventing sepsis in preterm infants remains uncertain. Adequately powered, random, controlled clinical trials of neutropenic infants are needed to further evaluate efficacy of these agents as adjuncts to antibiotic therapy. Carr and associates assert that available data do not support further study of rhG-CSF and rhGM-CSF in septic infants who are not neutropenic. A United Kingdom study of the efficacy of prophylactic GM-CSF in reducing systemic infection or mortality in infants at high risk for postnatal neutropenia is underway. No plans exist for a long-term follow-up study, however. Because infection has the potential to cause both short-term mortality and long-term neurologic disability, it is recommended that all future studies include long-term neurologic and neurodevelopmental follow-up. The next part of this series will explore the use of intravenous immunoglobulins to prevent and treat neonatal sepsis. |
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Authors:
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Susan Givens Bell |
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Publication Detail:
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Type: Editorial; Review |
Journal Detail:
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Title: Neonatal network : NN Volume: 25 ISSN: 0730-0832 ISO Abbreviation: Neonatal Netw Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503921 Medline TA: Neonatal Netw Country: United States |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: N |
Affiliation:
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University of South Florida, Tampa, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Administration Schedule Drug Monitoring / nursing Granulocyte Colony Stimulating Factor, Recombinant* / immunology, pharmacology, therapeutic use Granulocyte Macrophage Colony-Stimulating Factors, Recombinant* / immunology, pharmacology, therapeutic use Humans Infant, Newborn Leukocyte Count / methods Neonatal Nursing / methods Neutropenia / blood, diagnosis, drug therapy, nursing Neutrophils Randomized Controlled Trials as Topic Safety Sepsis / drug therapy, nursing Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Granulocyte Colony Stimulating Factor, Recombinant; 0/Granulocyte Macrophage Colony-Stimulating Factors, Recombinant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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