Document Detail


Immunomodulation, part II: granulocyte colony-stimulating factors.
MedLine Citation:
PMID:  16514867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although rhG-CSF and rhGM-CSF appear to have no adverse side effects, their usefulness in treating and preventing sepsis in preterm infants remains uncertain. Adequately powered, random, controlled clinical trials of neutropenic infants are needed to further evaluate efficacy of these agents as adjuncts to antibiotic therapy. Carr and associates assert that available data do not support further study of rhG-CSF and rhGM-CSF in septic infants who are not neutropenic. A United Kingdom study of the efficacy of prophylactic GM-CSF in reducing systemic infection or mortality in infants at high risk for postnatal neutropenia is underway. No plans exist for a long-term follow-up study, however. Because infection has the potential to cause both short-term mortality and long-term neurologic disability, it is recommended that all future studies include long-term neurologic and neurodevelopmental follow-up. The next part of this series will explore the use of intravenous immunoglobulins to prevent and treat neonatal sepsis.
Authors:
Susan Givens Bell
Related Documents :
20930597 - Multiple ecthyma gangrenosum in a healthy infant with community-acquired pseudomonas ae...
7017907 - Colonization of newborns with group b streptococci: relation to maternal urogenital car...
382837 - Group b streptococcal osteomyelitis and septic arthritis. its occurrence in infants les...
3538317 - Characteristic features of neonatal sepsis due to haemophilus influenzae.
3099267 - Intravenous immunoglobulin for prevention of sepsis in preterm and low birth weight inf...
8795357 - Crib (clinical risk index for babies) in relation to nosocomial bacteraemia in very low...
Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  Neonatal network : NN     Volume:  25     ISSN:  0730-0832     ISO Abbreviation:  Neonatal Netw     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8503921     Medline TA:  Neonatal Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  N    
Affiliation:
University of South Florida, Tampa, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Drug Administration Schedule
Drug Monitoring / nursing
Granulocyte Colony Stimulating Factor, Recombinant* / immunology,  pharmacology,  therapeutic use
Granulocyte Macrophage Colony-Stimulating Factors, Recombinant* / immunology,  pharmacology,  therapeutic use
Humans
Infant, Newborn
Leukocyte Count / methods
Neonatal Nursing / methods
Neutropenia / blood,  diagnosis,  drug therapy,  nursing
Neutrophils
Randomized Controlled Trials as Topic
Safety
Sepsis / drug therapy,  nursing
Treatment Outcome
Chemical
Reg. No./Substance:
0/Granulocyte Colony Stimulating Factor, Recombinant; 0/Granulocyte Macrophage Colony-Stimulating Factors, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Embracing bioethics in neonatal intensive care, part II: case histories in neonatal ethics.
Next Document:  Community-based, culturally appropriate oral health promotion program for immigrant pregnant women i...