Document Detail

Immunomodulation, part II: granulocyte colony-stimulating factors.
MedLine Citation:
PMID:  16514867     Owner:  NLM     Status:  MEDLINE    
Although rhG-CSF and rhGM-CSF appear to have no adverse side effects, their usefulness in treating and preventing sepsis in preterm infants remains uncertain. Adequately powered, random, controlled clinical trials of neutropenic infants are needed to further evaluate efficacy of these agents as adjuncts to antibiotic therapy. Carr and associates assert that available data do not support further study of rhG-CSF and rhGM-CSF in septic infants who are not neutropenic. A United Kingdom study of the efficacy of prophylactic GM-CSF in reducing systemic infection or mortality in infants at high risk for postnatal neutropenia is underway. No plans exist for a long-term follow-up study, however. Because infection has the potential to cause both short-term mortality and long-term neurologic disability, it is recommended that all future studies include long-term neurologic and neurodevelopmental follow-up. The next part of this series will explore the use of intravenous immunoglobulins to prevent and treat neonatal sepsis.
Susan Givens Bell
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  Neonatal network : NN     Volume:  25     ISSN:  0730-0832     ISO Abbreviation:  Neonatal Netw     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8503921     Medline TA:  Neonatal Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  N    
University of South Florida, Tampa, USA.
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MeSH Terms
Drug Administration Schedule
Drug Monitoring / nursing
Granulocyte Colony Stimulating Factor, Recombinant* / immunology,  pharmacology,  therapeutic use
Granulocyte Macrophage Colony-Stimulating Factors, Recombinant* / immunology,  pharmacology,  therapeutic use
Infant, Newborn
Leukocyte Count / methods
Neonatal Nursing / methods
Neutropenia / blood,  diagnosis,  drug therapy,  nursing
Randomized Controlled Trials as Topic
Sepsis / drug therapy,  nursing
Treatment Outcome
Reg. No./Substance:
0/Granulocyte Colony Stimulating Factor, Recombinant; 0/Granulocyte Macrophage Colony-Stimulating Factors, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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