| Immunomodulation of innate immune responses by vasoactive intestinal peptide (VIP): its therapeutic potential in inflammatory disease. | |
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MedLine Citation:
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PMID: 19604262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the late 1970s a number of laboratories have studied the role of vasoactive intestinal peptide (VIP) in inflammation and immunity. These studies have highlighted the dramatic effect of VIP on immune cell activation and function, and studies using animal models of disease have indicated that VIP has significant therapeutic and prophylactic potential. This review will focus on the effects of VIP on innate immune cell function and discuss the therapeutic potential for VIP in inflammatory diseases of humans. |
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Authors:
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S G R Smalley; P A Barrow; N Foster |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 157 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-16 Completed Date: 2009-09-10 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 225-34 Citation Subset: IM |
Affiliation:
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School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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immunology Dendritic Cells / immunology Humans Immune System Diseases / drug therapy, immunology*, metabolism Immunity, Innate Inflammation Mediators / metabolism Receptors, Vasoactive Intestinal Peptide / metabolism Toll-Like Receptors / metabolism Vasoactive Intestinal Peptide / physiology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Inflammation Mediators; 0/Receptors, Vasoactive Intestinal Peptide; 0/Toll-Like Receptors; 37221-79-7/Vasoactive Intestinal Peptide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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