| Immunomodulation in vitro. The predictive value of in vitro testing of lung cancer patients' lymphocyte responsiveness to stimulation by Thymex L. A preliminary report. | |
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MedLine Citation:
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PMID: 9387906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eleven lung cancer patients were selected for combined radio and immunotherapy with a thymic agent-Thymex L. The selection criteria included the pre-therapy testing of patients' immunocompetence and the responsiveness of their lymphocytes to the in vitro addition of Thymex L: only patients with a significant degree of immunodepression, whose depressed cellular immunity parameters (the number of total and active T cells and their mitogen-induced lymphoproliferative response) were significantly increased upon this agent's action in vitro, entered the study. The results of the pre-therapy in vitro stimulation correlated with those obtained after completion of radioimmunotherapy: the administration of Thymex L along with radiotherapy seances prevented iatrogenic deterioration of initial depression of general immunocompetence and enabled to overcome it to a certain degree. This indicates that pre-therapy in vitro testing has a true predictive value. However, the initial immune disturbances were not normalized by immunotherapy; the post-therapy testing of the patients' lymphocytes to the addition of Thymex L in vitro showed that these cells possessed a residual potential to respond by a significant increase of the active T cell number and proliferative capacity, suggesting that immunotherapy could be prolonged in order to potentiate cellular immunity in immunodepressed lung cancer patients. |
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Authors:
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L Vucković-Dekić; N Stanojević-Bakić; L Rajner; M Dekić; M Pesić |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of experimental & clinical cancer research : CR Volume: 16 ISSN: 0392-9078 ISO Abbreviation: J. Exp. Clin. Cancer Res. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1998-01-27 Completed Date: 1998-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308647 Medline TA: J Exp Clin Cancer Res Country: ITALY |
Other Details:
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Languages: eng Pagination: 309-12 Citation Subset: IM |
Affiliation:
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Institute for Oncology and Radiology of Serbia, Beograd, Yugoslavia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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therapeutic use* Combined Modality Therapy Humans Immunologic Tests Immunotherapy Lung Neoplasms / immunology*, radiotherapy, therapy* Lymphocyte Activation / drug effects*, immunology* Phytohemagglutinins / pharmacology Predictive Value of Tests Stimulation, Chemical T-Lymphocytes / drug effects*, immunology* Thymus Extracts / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Phytohemagglutinins; 0/Thymus Extracts; 104841-70-5/Thymex-L |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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