Document Detail


Immunomodulation in transfused trauma patients.
MedLine Citation:
PMID:  23303513     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Traumatic injury is a major human health problem, with many injured people supported by transfusion of allogeneic blood. Although trauma and transfusion have both been known to have immunomodulatory effects for some time, little is known about their combined effects or the scope and kinetics of such responses.
RECENT FINDINGS: Traumatic injury has a profound immunomodulatory effect on the patient, affecting a broad array of immunological components. This can be further complicated by transfusion, though the contribution of transfusion relative to the massive response triggered by trauma is small. The response to trauma involves a strong immunosuppressive component, which, contrary to the systemic inflammatory response syndrome/compensatory anti-inflammatory response syndrome model, occurs at the earliest time points examined and overlaps with proinflammatory and antimicrobial elements. This response is remarkably similar in a wide range of patients with different types and severities of injury.
SUMMARY: The response to trauma and transfusion involves a massive and rapid reorganization of the immune system that can put the patient at increased risk of infection, tissue damage, and organ failure. The scope of the response presents challenges to the development of treatments to control this dysregulation.
Authors:
Rachael P Jackman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in anaesthesiology     Volume:  26     ISSN:  1473-6500     ISO Abbreviation:  Curr Opin Anaesthesiol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-14     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8813436     Medline TA:  Curr Opin Anaesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Transfusion*
Humans
Immunomodulation*
Inflammation / immunology
Stress, Physiological
Wounds and Injuries / immunology*,  therapy
Grant Support
ID/Acronym/Agency:
R01 HL-083388/HL/NHLBI NIH HHS; R01 HL083388/HL/NHLBI NIH HHS
Comments/Corrections

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