Document Detail

Immunomodulation in schizophrenia: A study among the Indian schizophrenia patients of Siliguri, West Bengal.
MedLine Citation:
PMID:  23051162     Owner:  NLM     Status:  In-Data-Review    
Authors investigated the circumstantial evidence for autoimmunity in schizophrenia patients of Siliguri by considering the immune parameters like HLA Class I genes, IL-2 and IL6 and T cell subsets. Low resolution PCR-SSP method was applied for typing the HLA genes. Serum levels of IL-2 and IL-6 were measured by ELISA method. The CD4+ and CD8+ subset count were done using flow cytometry. A significant increase in HLA A*03 gene was observed in patients along with the significant decrease of HLA-A*31 and HLA-B*51. Both IL-2 and IL-6 were found to have decreased levels in the patients. Although the mean percentage of CD4+ and CD8+ cells was higher in patients but not significantly higher than controls. These cumulative preliminary findings are suggestive of alterations in the immune system of schizophrenia patients of this region.
Bisu Singh; Nirmal Kumar Bera; Chitta R Nayak; Tapas Kumar Chaudhuri
Publication Detail:
Type:  Journal Article     Date:  2011-10-12
Journal Detail:
Title:  Asian journal of psychiatry     Volume:  4     ISSN:  1876-2026     ISO Abbreviation:  Asian J Psychiatr     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517820     Medline TA:  Asian J Psychiatr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri 734 430, West Bengal, India.
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