Document Detail


Immunomodulation in schizophrenia: A study among the Indian schizophrenia patients of Siliguri, West Bengal.
MedLine Citation:
PMID:  23051162     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Authors investigated the circumstantial evidence for autoimmunity in schizophrenia patients of Siliguri by considering the immune parameters like HLA Class I genes, IL-2 and IL6 and T cell subsets. Low resolution PCR-SSP method was applied for typing the HLA genes. Serum levels of IL-2 and IL-6 were measured by ELISA method. The CD4+ and CD8+ subset count were done using flow cytometry. A significant increase in HLA A*03 gene was observed in patients along with the significant decrease of HLA-A*31 and HLA-B*51. Both IL-2 and IL-6 were found to have decreased levels in the patients. Although the mean percentage of CD4+ and CD8+ cells was higher in patients but not significantly higher than controls. These cumulative preliminary findings are suggestive of alterations in the immune system of schizophrenia patients of this region.
Authors:
Bisu Singh; Nirmal Kumar Bera; Chitta R Nayak; Tapas Kumar Chaudhuri
Publication Detail:
Type:  Journal Article     Date:  2011-10-12
Journal Detail:
Title:  Asian journal of psychiatry     Volume:  4     ISSN:  1876-2026     ISO Abbreviation:  Asian J Psychiatr     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517820     Medline TA:  Asian J Psychiatr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri 734 430, West Bengal, India.
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