| Immunomodulation in gut-associated lymphoid tissue of neonatal chicks by immunobiotic diets. | |
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MedLine Citation:
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PMID: 19903951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Developmental changes in immunocompetent cells of the gut during the first week posthatch were determined in broiler chicks fed immunobiotic lactic acid bacteria in the form of Lactobacillus jensenii TL2937-, Lactobacillus gasseri JCM1131(T)-, Lactobacillus delbrueckii ssp. bulgaricus NIAIB6-, or L. gasseri TL2919-supplemented diets. The relative weights of spleen and bursa of Fabricius in chicks fed the immunobiotic diets were slightly higher than the control valued at 1 and 3 d of age, with the exception of spleen weight in the L. gasseri JCM1131(T) at 3 d of age, the bursa of Fabricius weight in the L. gasseri JCM1131(T) at 1 and 3 d of age, and bursa of Fabricius weight in the L. gasseri TL2919 group at 1 d of age. There were no significant differences in body and liver weights among the treatments. When chicks were fed the L. jensenii TL2937- or L. gasseri TL2919-supplemented diets, expression of T cell-related mRNA [cluster of differentiation 3 (CD3), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma)] in the foregut was significantly higher than that of control chicks at 3 or 7 d of age. Expression levels of toll-like receptor (TLR) mRNA tended to increase in the foregut of chicks fed the immunobiotic diets, except for the L. delbrueckii ssp. bulgaricus NIAIB6, compared with expression levels in control chicks. The Bu-1 mRNA expression levels in the bursa of Fabricius were not affected by the supplementations with immunobiotic lactic acid bacteria. These results show that immunobiotics, particularly L. gasseri TL2919, might be useful as immunomodulators to stimulate the gut-associated immune system in neonatal chicks, and thereby protect them from disease without decreasing growth performance as a possible substitution of antibiotics. |
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Authors:
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K Sato; K Takahashi; M Tohno; Y Miura; T Kamada; S Ikegami; H Kitazawa |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Poultry science Volume: 88 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2532-8 Citation Subset: IM |
Affiliation:
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Department of Biological Production, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan. satokan@cc.tuat.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animal Nutritional Physiological Phenomena Animals Animals, Newborn B-Lymphocytes / physiology Bursa of Fabricius / physiology* Chickens* Cytokines / genetics, metabolism Diet / veterinary* Gene Expression Regulation / physiology Immunomodulation / drug effects* Lactobacillus Lymphoid Tissue / physiology* Male RNA, Messenger / metabolism T-Lymphocytes / physiology Toll-Like Receptors / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/RNA, Messenger; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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