Document Detail

Immunomodulation by polyunsaturated fatty acids: impact on T-cell signaling.
MedLine Citation:
PMID:  15736912     Owner:  NLM     Status:  MEDLINE    
In recent years the potential application of the immunomodulatory effects of polyunsaturated FA (PUFA), particularly those of the n-3 series, in a variety of inflammatory disorders has been of considerable interest. However, the mechanisms underlying inhibition of T-cell activation have so far been unclear. In this short review we summarize possible mechanisms for the modulation of immune responses by PUFA. Effects of PUFA on T-cell signal transduction pathways and underlying molecular mechanisms are described in detail. These recent results add considerably to the understanding of mechanisms of PUFA actions, but their relevance in the in vivo situation must still be elucidated.
Thomas M Stulnig; Maximilian Zeyda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lipids     Volume:  39     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-03-01     Completed Date:  2005-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1171-5     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria.
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MeSH Terms
Fatty Acids, Unsaturated / chemistry,  pharmacology*
Immunologic Factors / chemistry,  pharmacology
Membrane Microdomains / chemistry
Signal Transduction*
T-Lymphocytes / chemistry,  drug effects,  immunology*
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Immunologic Factors

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