Document Detail


Immunomodulation by the new synthetic thiazole derivative tiprotimod. 1st communication: synthesis and structure-activity relationships.
MedLine Citation:
PMID:  2783178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of carboxyalkylthio-substituted thiazole-carboxylic acids was synthesized and examined for macrophage activation and stimulation of the DTH (delayed type of hypersensitivity)-reaction. The structure-activity relationship in this series of new immunomodulators is discussed. Broadest immunological activity was seen for [2-(3-carboxy-1-propylthio)-4-methyl-1,3-thiazole]acetic acid (tiprotimod, HBW 538) which was selected for further studies.
Authors:
K Fleischmann; K H Scheunemann; H U Schorlemmer; G Dickneite; J Blumbach; G Fischer; W Dürckheimer; H H Sedlacek
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  39     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  743-6     Citation Subset:  IM    
Affiliation:
Research Laboratories of Pharma Research, Frankfurt Main, Fed. Rep. of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chemical Phenomena
Chemistry
Erythrocytes / immunology
Female
Hypersensitivity, Delayed / immunology
Immunosuppressive Agents / chemical synthesis*,  pharmacology
Luminescent Measurements
Macrophages / drug effects,  enzymology
Mice
Sheep / immunology
Structure-Activity Relationship
Thiazoles / chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Thiazoles; 105523-37-3/tiprotimod

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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