| Immunomodulation by the new synthetic thiazole derivative tiprotimod. 1st communication: synthesis and structure-activity relationships. | |
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MedLine Citation:
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PMID: 2783178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of carboxyalkylthio-substituted thiazole-carboxylic acids was synthesized and examined for macrophage activation and stimulation of the DTH (delayed type of hypersensitivity)-reaction. The structure-activity relationship in this series of new immunomodulators is discussed. Broadest immunological activity was seen for [2-(3-carboxy-1-propylthio)-4-methyl-1,3-thiazole]acetic acid (tiprotimod, HBW 538) which was selected for further studies. |
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Authors:
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K Fleischmann; K H Scheunemann; H U Schorlemmer; G Dickneite; J Blumbach; G Fischer; W Dürckheimer; H H Sedlacek |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 39 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-10-26 Completed Date: 1989-10-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 743-6 Citation Subset: IM |
Affiliation:
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Research Laboratories of Pharma Research, Frankfurt Main, Fed. Rep. of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemical Phenomena Chemistry Erythrocytes / immunology Female Hypersensitivity, Delayed / immunology Immunosuppressive Agents / chemical synthesis*, pharmacology Luminescent Measurements Macrophages / drug effects, enzymology Mice Sheep / immunology Structure-Activity Relationship Thiazoles / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Thiazoles; 105523-37-3/tiprotimod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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