Document Detail

Immunomodulation by a malleable matrix composed of fermented whey proteins and lactic acid bacteria.
MedLine Citation:
PMID:  17472469     Owner:  NLM     Status:  MEDLINE    
Functional foods and nutraceuticals have gained in popularity over the last 10 years. Among natural health products, whey proteins and fermented milk products are paramount. A malleable protein matrix (MPM), composed of whey fermented by a lactic acid bacterium, capsular exopolysaccharides, vitamins, minerals, and peptides generated during the fermentation process, has the potential to be unique by combining multiple health-promoting components. Forced feeding experiments on healthy animals were performed to evaluate the immunomodulatory effect of MPM. Glutathione production, antibody response, and the modulation of leukocyte populations were monitored. The stimulation of the immune system by MPM consumption was evident as seen by the increased polymorphonuclear cell counts and intracellular glutathione levels. The absence of MPM-specific antibody production indicated a lack of undesirable immune recognition of MPM. The MPM, with its immunomodulatory properties, has the potential to be a food substitute or a functional food for maintenance of general immune health.
Josée Beaulieu; Roger Dubuc; Nicolas Beaudet; Claude Dupont; Pierre Lemieux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal food     Volume:  10     ISSN:  1096-620X     ISO Abbreviation:  J Med Food     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Institut National de la Recherche Scientifique-Institut Armand-Frappier, Laval, Québec, Canada.
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MeSH Terms
Antibody Formation
Dietary Proteins / administration & dosage*,  analysis
Glutathione / blood
Health Promotion
Immunity / drug effects*
Lactobacillus / metabolism*
Leukocyte Count
Milk Proteins / administration & dosage*,  metabolism
Rats, Inbred Lew
Rats, Wistar
Reg. No./Substance:
0/Dietary Proteins; 0/Milk Proteins; 0/whey protein; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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