Document Detail


Immunomodulation by 8-week voluntary exercise in mice.
MedLine Citation:
PMID:  10712579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to evaluate the effects of voluntary exercise on macrophage and lymphocyte functions in mice. Male A/He inbred mice aged 19 weeks were divided into two groups: a group given voluntary exercise and a control group (n = 10 in each group). Exercise consisted of spontaneous running in wheels for 8 weeks (3 days week-1). Glucose consumption of peritoneal macrophages in the exercise group during incubation up to 72 h was significantly higher than that in the control group (70 and 13%, respectively). Also, activities of acid phosphatase (APH) (10.75 +/- 0.37 IU), beta-glucuronidase (GLU) (1.55 +/- 0.07 IU) and lactate dehydrogenase (LDH) (43.3 +/- 0.7 IU) in the peritoneal macrophages in the exercise group was significantly increased (P < 0.01). Compared with the control group, the exercise group had a significant increase of about twofold in macrophage production of nitric oxide (NO2-) stimulated by lipopolysaccharide (LPS) (11.1 +/- 0.1 vs. 5.9 +/- 0.1 microM mL-1 in exercise and control groups, respectively; P < 0.01). Stimulation indices both by concanavalin A (Con A) and phytohaemagglutinin were also significantly higher in the exercise group (P < 0.01). A significant increase in the splenocyte production of interleukin-2 (IL-2) stimulated by Con A was noticed in the exercise group (354.1 +/- 28.8 vs. 218.9 +/- 23.5 pg mL-1 in exercise and control groups, respectively; P < 0.01). These findings suggest that voluntary exercise enhances not only macrophage function but also lymphocyte responsiveness in mice. In the studies of voluntary exercise, evaluation of NO2- production, as an indicator of macrophage function, is recommended.
Authors:
H Sugiura; H Nishida; R Inaba; S M Mirbod; H Iwata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  168     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-21     Completed Date:  2000-04-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  413-20     Citation Subset:  IM    
Affiliation:
Department of Health and Physical Education, Gifu Pharmaceutical University, 5-6-1 Mitahora higashi, Gifu, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / metabolism
Animals
Concanavalin A / pharmacology
Glucose / metabolism
Glucuronidase / metabolism
Immunity*
Interleukin-2 / biosynthesis
L-Lactate Dehydrogenase / metabolism
Lymphocyte Activation
Lymphocytes / immunology
Macrophage Activation
Macrophages, Peritoneal / immunology,  metabolism
Male
Mice
Mice, Inbred A
Motor Activity / immunology
Nitric Oxide / biosynthesis
Physical Exertion / physiology*
Phytohemagglutinins / pharmacology
Chemical
Reg. No./Substance:
0/Interleukin-2; 0/Phytohemagglutinins; 10102-43-9/Nitric Oxide; 11028-71-0/Concanavalin A; 50-99-7/Glucose; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 3.1.3.2/Acid Phosphatase; EC 3.2.1.31/Glucuronidase

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