Document Detail

Immunomodulation, Part V: probiotics.
MedLine Citation:
PMID:  17285888     Owner:  NLM     Status:  MEDLINE    
The five-part "Pointers in Practical Pharmacology" immunomodulation series has presented some of the agents researchers are investigating in hopes of finding the means to effectively prevent and treat infectious processes in neonates. The phosphodiesterase inhibitor pentoxifylline appears promising, but large, randomized, clinical trials are still lacking. So far, there is no clear evidence to support the use of G-CSF for either the prevention or the treatment of sepsis. The results of a large, randomized, clinical trial of G-CSF in the United Kingdom are pending. Although intravenous immunoglobulin (IVIG) therapy does not appear to be useful in the prevention of sepsis, its effectiveness in the treatment of sepsis is uncertain. It is hoped that the results of the International Neonatal Immunotherapy Study will provide definitive answers regarding treatment of sepsis with IVIG. The "conditionally essential" amino acid glutamine administered either enterally or parenterally does not make a difference in the rate of systemic infection or NEC in very low birth weight infants. Finally, probiotics appear promising as documented by at least two of the three randomized, clinical trials described here. As the search continues for agents to enhance the neonate's immune system and prevent and treat infectious diseases, remember that our best prevention tool is excellent and consistent hand hygiene.
Susan Givens Bell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neonatal network : NN     Volume:  26     ISSN:  0730-0832     ISO Abbreviation:  Neonatal Netw     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-03-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8503921     Medline TA:  Neonatal Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  N    
All Children's Hospital, Saint Petersburg, Florida, USA.
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MeSH Terms
Adjuvants, Immunologic / pharmacology,  therapeutic use*
Bottle Feeding
Breast Feeding
Enteral Nutrition
Enterocolitis, Necrotizing / immunology,  prevention & control*
Immunity, Mucosal / drug effects,  immunology
Infant, Newborn / immunology
Infant, Premature / immunology
Intensive Care, Neonatal
Intestinal Mucosa / drug effects,  immunology
Practice Guidelines as Topic
Probiotics / pharmacology,  therapeutic use*
Randomized Controlled Trials as Topic
Sepsis / immunology,  prevention & control*
Treatment Outcome
Reg. No./Substance:
0/Adjuvants, Immunologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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