Document Detail


Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium).
MedLine Citation:
PMID:  11732754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of CVT-E002, an aqueous extract containing mainly oligosaccharides and polysaccharides from North American ginseng (Panax quinquefolium), as an immunobooster on murine spleen cells and peritoneal macrophages, was studied in-vitro. CVT-E002 stimulated the proliferation of normal mouse spleen cells, of which the major responding subpopulation was identified as B lymphocytes. CVT-E002 also activated peritoneal exudate macrophages leading to enhanced interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production. In addition, CVT-E002 stimulated in-vivo immunoglobulin G (IgG) production in treated mice. These results identify some of the immunomodulating activities of CVT-E002 and suggest its use clinically for the modulation of immune responses.
Authors:
M Wang; L J Guilbert; L Ling; J Li; Y Wu; S Xu; P Pang; J J Shan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  53     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-04     Completed Date:  2002-04-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1515-23     Citation Subset:  IM    
Affiliation:
CV Technologies Inc, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology*
Animals
Cell Division / drug effects
Dose-Response Relationship, Drug
Immunity, Innate / drug effects
Immunoglobulin G / blood,  drug effects
Interleukin-1 / metabolism
Interleukin-6 / metabolism
Macrophages / drug effects,  metabolism
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Nitric Oxide / metabolism
Panax / chemistry*
Plant Extracts / pharmacology*
Spleen / cytology,  drug effects
Tumor Necrosis Factor-alpha / metabolism
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Immunoglobulin G; 0/Interleukin-1; 0/Interleukin-6; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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