| Immunology of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 20576205 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The conceptual framework for reproductive immunology was put in place over 50 years ago when the survival of the fetal semi-allograft within an immunocompetent mother was first considered. During this time, a number of paradigms have emerged and the mechanisms receiving current attention are those related to immune tolerance, such as regulatory T-cells and indoleamine 2,3,-dioxygenase, and innate immunity, such as natural killer cells, trophoblast debris and inflammation. A key consideration is the temporal and spatial variation in any of these pathways (e.g. implantation v. parturition). As fetally derived trophoblasts are the semi-allogeneic cells with which the maternal immune system comes into contact, understanding the immune response to these cells is critical. There is much interest in the immunological pathways that support a healthy pregnancy and how they might be perturbed in adverse pregnancy outcomes. Additionally, there is increasing awareness that antenatal determinants of the immune function of pregnant women and their offspring have consequences for health and disease in childhood and beyond. Changes in maternal diet over recent decades coincide with the increasing prevalence of allergic and other immune-mediated diseases, and the modification of maternal diet has emerged as a strategy for disease prevention. Approaches undergoing trial at numerous sites around the world include dietary supplementation with fish oil and/or probiotics. Understanding the underlying mechanisms of any positive effect on disease outcomes should reveal further novel strategies for disease prevention. |
| | |
Authors:
|
Catherine A Thornton |
Related Documents
:
|
2517035 - Effect of pregnancy plasma upon in vitro parameters of cell mediated immunity. 190745 - Syngeneic antitumor and antiembryo immunization affecting pregnancy in mice. 15519425 - Prevention and management of rhd isoimmunization. 8363725 - Bidirectional cytokine interactions in the maternal-fetal relationship: is successful p... 8441215 - Health behavior and outcomes in sequential pregnancies of black and white adolescents. 18440515 - Less is more: increased gonadotropin use for ovarian stimulation adversely influences c... |
Publication Detail:
|
Type: Journal Article Date: 2010-06-25 |
Journal Detail:
|
Title: The Proceedings of the Nutrition Society Volume: 69 ISSN: 0029-6651 ISO Abbreviation: Proc Nutr Soc Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7505881 Medline TA: Proc Nutr Soc Country: England |
Other Details:
|
Languages: eng Pagination: 357-65 Citation Subset: IM |
Affiliation:
|
Institute of Life Science, School of Medicine, Swansea University, Swansea SA2 8PP, UK. c.a.thornton@swansea.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A rat model of mild intestinal inflammation induced by Staphylococcus aureus enterotoxin B.
Next Document: Ultrastructure of in vitro oocyte maturation in buffalo (Bubalus bubalis).