Document Detail

Immunology of placentation in eutherian mammals.
MedLine Citation:
PMID:  16868549     Owner:  NLM     Status:  MEDLINE    
The traditional way to study the immunology of pregnancy follows the classical transplantation model, which views the fetus as an allograft. A more recent approach, which is the subject of this Review, focuses on the unique, local uterine immune response to the implanting placenta. This approach requires knowledge of placental structure and its variations in different species, as this greatly affects the type of immune response that is generated by the mother. At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not.
Ashley Moffett; Charlie Loke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  6     ISSN:  1474-1733     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-26     Completed Date:  2006-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  584-94     Citation Subset:  IM    
King's College, Cambridge CB2 1ST, UK.
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MeSH Terms
HLA Antigens / immunology
Killer Cells, Natural / cytology,  immunology
Mammals / embryology,  immunology*
Placentation / immunology*,  physiology
Trophoblasts / cytology,  immunology,  physiology
Uterus / cytology,  immunology,  physiology
Reg. No./Substance:
0/HLA Antigens

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