| Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis. | |
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MedLine Citation:
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PMID: 22385235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections. Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune diseases is an open issue. Enteroviruses, especially Coxsackievirus B4 (CV-B4), have been largely suggested as potential inducers or aggravating factors of type 1 diabetes (T1D) pathogenesis in genetically predisposed individuals. Several pathogenic mechanisms of enterovirus-induced T1D have been suggested. One of these mechanisms is the impairment of central self-tolerance due to viral infections. Coxsackievirus-B4 is able to infect murine thymus in vitro and in vivo and to infect human thymus in vitro. Thymic epithelial cells and thymocytes are targets of infection with this virus, and several abnormalities, especially disturbance of maturation/differentiation processes, were observed. Altogether, these data suggest that CV-B infection of thymus may be involved in the pathogenesis of T1D. Further investigations are needed to explore this hypothesis. |
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Authors:
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H Jaïdane; F Sané; R Hiar; A Goffard; J Gharbi; V Geenen; D Hober |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 168 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-05-04 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 39-46 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
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Université Lille 2, CHRU Laboratoire de virologie EA3610, Institut Hippocrate CHRU, 152 Rue du Dr Yersin, Loos-lez-Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / virology Coxsackievirus Infections / immunology, virology Diabetes Mellitus, Type 1 / genetics, immunology*, virology* Enterovirus B, Human / immunology, pathogenicity Genetic Predisposition to Disease Humans Mice Self Tolerance / immunology T-Lymphocytes / immunology, virology Thymocytes / immunology, virology Thymus Gland / immunology*, virology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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