| Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy. | |
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MedLine Citation:
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PMID: 22132881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is no approved therapy for food allergy. The current standard of care is elimination of the triggering food from the diet and accessibility to epinephrine. Immunotherapy is a promising treatment approach. While desensitization to most foods seems feasible, it remains unclear if a permanent state of tolerance is achievable. The research team at Duke is pioneering immunotherapy for food allergies. Work here has evolved over time from small open-label pilot studies to larger randomized designs. Our data show that immunological changes associated with immunotherapy include reduction in mast cell reactivity, decreased basophil responses, decreased specific-immunoglobulin (Ig)E, increased IgG4 and induction of regulatory T cells. Immunotherapy has generated much excitement in the food allergy community; however, further studies are needed before it is ready for clinical use. |
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Authors:
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T Mousallem; A W Burks |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 167 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-02 Completed Date: 2012-01-23 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 26-31 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology. |
Affiliation:
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Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Administration, Sublingual Allergens / administration & dosage, therapeutic use Arachis hypogaea / adverse effects, immunology Basophils / immunology Desensitization, Immunologic* / methods Double-Blind Method Egg Proteins / adverse effects, therapeutic use Epinephrine / therapeutic use Food Hypersensitivity / diet therapy, drug therapy, therapy* Humans Immune Tolerance Immunoglobulin E / immunology Immunoglobulin G / immunology Injections, Subcutaneous Mast Cells / immunology Milk Hypersensitivity / therapy Milk Proteins / adverse effects, therapeutic use Nut Hypersensitivity / therapy Pilot Projects Randomized Controlled Trials as Topic T-Lymphocytes, Regulatory / immunology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Egg Proteins; 0/Immunoglobulin G; 0/Milk Proteins; 37341-29-0/Immunoglobulin E; 51-43-4/Epinephrine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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