Document Detail


Immunology in the Clinic Review Series; focus on allergies: immunotherapy for food allergy.
MedLine Citation:
PMID:  22132881     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is no approved therapy for food allergy. The current standard of care is elimination of the triggering food from the diet and accessibility to epinephrine. Immunotherapy is a promising treatment approach. While desensitization to most foods seems feasible, it remains unclear if a permanent state of tolerance is achievable. The research team at Duke is pioneering immunotherapy for food allergies. Work here has evolved over time from small open-label pilot studies to larger randomized designs. Our data show that immunological changes associated with immunotherapy include reduction in mast cell reactivity, decreased basophil responses, decreased specific-immunoglobulin (Ig)E, increased IgG4 and induction of regulatory T cells. Immunotherapy has generated much excitement in the food allergy community; however, further studies are needed before it is ready for clinical use.
Authors:
T Mousallem; A W Burks
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  167     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-01-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  26-31     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.
Affiliation:
Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Administration, Sublingual
Allergens / administration & dosage,  therapeutic use
Arachis hypogaea / adverse effects,  immunology
Basophils / immunology
Desensitization, Immunologic* / methods
Double-Blind Method
Egg Proteins / adverse effects,  therapeutic use
Epinephrine / therapeutic use
Food Hypersensitivity / diet therapy,  drug therapy,  therapy*
Humans
Immune Tolerance
Immunoglobulin E / immunology
Immunoglobulin G / immunology
Injections, Subcutaneous
Mast Cells / immunology
Milk Hypersensitivity / therapy
Milk Proteins / adverse effects,  therapeutic use
Nut Hypersensitivity / therapy
Pilot Projects
Randomized Controlled Trials as Topic
T-Lymphocytes, Regulatory / immunology
Chemical
Reg. No./Substance:
0/Allergens; 0/Egg Proteins; 0/Immunoglobulin G; 0/Milk Proteins; 37341-29-0/Immunoglobulin E; 51-43-4/Epinephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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