Document Detail

Immunology of diabetes mellitus.
MedLine Citation:
PMID:  1736719     Owner:  NLM     Status:  MEDLINE    
Insulin-dependent diabetes is an autoimmune disease that may be becoming more prevalent. It has a polygenic mode of inheritance with a major gene being present in the HLA DQ locus on chromosome 6. Inferential data suggest that environmental factors may be important to genetic penetrance albeit we still lack proof for involvement of often maligned viruses. Patients with IDD and their families are predisposed to organ-specific autoimmunities which should be routinely screened for. Autoantibodies to insulin, to a beta cell cytoplasmic lipid containing moiety and to a beta cell protein of 64KDa, which is believed to be the GABA forming enzyme GAD, can be used to predict IDD among relatives and probably the general population as well. Immunosuppressive therapy can modify the course of IDD after diagnosis and should be able to delay the clinical onset if given before diagnosis. Rigorous insulin therapy should also be given as needed to control hyperglycemia and avoid glucose toxicity to the islets. Such trials are now underway.
N Maclaren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of allergy     Volume:  68     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, U of Florida College of Medicine, Gainesville.
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MeSH Terms
Autoimmune Diseases / physiopathology
Diabetes Mellitus, Type 1 / diagnosis,  genetics,  immunology*,  microbiology,  therapy
Genes, MHC Class II
HLA Antigens / genetics
Reg. No./Substance:
0/HLA Antigens
Comment In:
Ann Allergy. 1993 Jul;71(1):80-1   [PMID:  8328719 ]

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