| Immunology of pre-eclampsia. | |
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MedLine Citation:
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PMID: 20331588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pre-eclampsia develops in stages, only the last being the clinical illness. This is generated by a non-specific, systemic (vascular), inflammatory response, secondary to placental oxidative stress and not by reactivity to fetal alloantigens. However, maternal adaptation to fetal (paternal alloantigens) is crucial in the earlier stages. A pre-conceptual phase involves maternal tolerization to paternal antigens by seminal plasma. After conception, regulatory T cells, interacting with indoleamine 2,3-dioxygenase, together with decidual NK cell recognition of fetal HLA-C on extravillous trophoblast may facilitate placental growth by immunoregulation. Complete failure of this mechanism would cause miscarriage, while partial failure would cause poor placentation and dysfunctional uteroplacental perfusion. The first pregnancy preponderance and partner specificity of pre-eclampsia can be explained by this model. For the first time, the pathogenesis of pre-eclampsia can be related to defined immune mechanisms that are appropriate to the fetomaternal frontier. Now, the challenge is to prove the detail. |
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Authors:
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Christopher W G Redman; Ian L Sargent |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-03-23 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 534-43 Citation Subset: IM |
Affiliation:
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Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK. christopher.redman@obs-gyn.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Fetus / immunology Humans Inflammation Killer Cells, Natural / immunology Mice Oxidative Stress Placenta / immunology, pathology Pre-Eclampsia / immunology*, pathology* Pregnancy T-Lymphocytes, Regulatory / immunology Trophoblasts / immunology |
| Grant Support | |
ID/Acronym/Agency:
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GR079862MA//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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