Document Detail

Immunology and clinical manifestations of non-clonal mast cell activation syndrome.
MedLine Citation:
PMID:  23212667     Owner:  NLM     Status:  MEDLINE    
There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment.
Juan-Carlos Cardet; Mariana C Castells; Matthew J Hamilton
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  13     ISSN:  1534-6315     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-04-17     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-8     Citation Subset:  IM    
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MeSH Terms
Mast Cells / immunology*
Mastocytosis, Systemic / diagnosis*,  immunology*,  therapy
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