Document Detail


Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection.
MedLine Citation:
PMID:  22997085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The majority of patients infected with human T-cell lymphotropic virus-type 1 (HTLV-1) are considered carriers, but a high frequency of urinary symptoms of overactive bladder, common in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) have been documented in these patients. The aim of this study was to determine if immunological and viral factors that are seen in HAM/TSP are also observed in these patients. Participants were classified as HTLV-1 carriers (n = 45), HTLV-1 patients suffering from overactive bladder (n = 45) and HAM/TSP (n = 45). Cells from HTLV-1 overactive bladder patients produced spontaneously more proinflammatory cytokines than carriers. TNF-α and IL-17 levels were similar in HAM/TSP and HTLV-1 overactive bladder patients. High proviral load was found in patients with overactive bladder and HAM/TSP and correlated with proinflammatory cytokines. In contrast with findings in patients with HAM/TSP, serum levels of Th1 chemokines were similar in HTLV-1 overactive bladder and carriers. Exogenous addition of regulatory cytokines decreased spontaneous IFN-γ production in cell cultures from HTLV-1 overactive bladder patients. The results show that HTLV-1 overactive bladder and HAM/TSP patients have in common some immunological features as well as similar proviral load profile. The data show that HTLV-1 overactive bladder patients are still able to down regulate their inflammatory immune response. In addition, these patients express levels of chemokines similar to carriers, which may explain why they have yet to develop the same degree of spinal cord damage as seen in patients with HAM/TSP. These patients present symptoms of overactive bladder, which may be an early sign of HAM/TSP.
Authors:
Silvane Braga Santos; Paulo Oliveira; Tania Luna; Anselmo Souza; Márcia Nascimento; Isadora Siqueira; Davi Tanajura; André Luiz Muniz; Marshall J Glesby; Edgar M Carvalho
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  84     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-21     Completed Date:  2013-01-28     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1809-17     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Immunology Service, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, Bahia, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cross-Sectional Studies
Cytokines / secretion
Female
HTLV-I Infections / complications*,  immunology*,  virology
Human T-lymphotropic virus 1 / isolation & purification*
Humans
Leukocytes, Mononuclear / immunology
Male
Middle Aged
Proviruses / isolation & purification
Urinary Bladder, Overactive / immunology*,  virology
Viral Load
Grant Support
ID/Acronym/Agency:
AI079238/AI/NIAID NIH HHS; K24 AI078884/AI/NIAID NIH HHS; R01 AI079238/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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