Document Detail

Immunological tolerance in chickens hatching from eggs injected with cell-associated herpesvirus of Turkey (HVT).
MedLine Citation:
PMID:  12631525     Owner:  NLM     Status:  MEDLINE    
Cell-associated herpesvirus of turkeys (HVT) was inoculated in ovo at various stages of incubation. Chickens hatching from these eggs were tested for anti-HVT antibodies by several serologic procedures including enzyme-linked immunosorbent assay, indirect immunofluorescence assays, and western blot. Viremic chickens that remained free of detectable antibodies were considered tolerant to HVT. Chickens exposed to HVT at embryonation day 14 or earlier had 6-33% incidence of tolerance. Tolerant chickens developed persistent HVT viremia. A preliminary challenge experiment provided circumstantial evidence that tolerant to HVT may be associated with reduced resistance to virulent Marek's disease virus. Tolerance to HVT did not influence the ability of the chickens to produce antibodies against an extraneous antigen or respond to a T cell mitogen.
Y Zhang; J M Sharma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  27     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-03-12     Completed Date:  2003-11-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-8     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Elsevier Science Ltd.
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, 258 Veterinary Science Building, 1971 Commonwealth Avenue, St Paul, MN 55108, USA.
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MeSH Terms
Antibodies, Viral / biosynthesis
Brucella abortus / immunology
Chick Embryo
Chickens / growth & development,  immunology*,  virology*
Herpesvirus 1, Meleagrid / immunology*
Immune Tolerance*
Ovum / immunology,  virology
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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