Document Detail

Immunological studies of newborn infants with hyperbilirubinemia.
MedLine Citation:
PMID:  7307646     Owner:  NLM     Status:  MEDLINE    
In order to study the immunocompetence of severely jaundiced newborn infants and the possible role of infection in the pathogenesis of neonatal hyperbilirubinemia, 74 newborn infants with varying degree of jaundice were studied with respect to several immunological parameters. The results showed that neonates with total serum bilirubin more than 20 mg/dl had statistically significantly higher numbers of white blood cells (WBCs), band form granulocytes, polymorphonuclear leukocytes (PMNs) and monocytes with Fc and complement (C') receptors and elevated serum IgM than did those with lower serum bilirubin. It is therefore concluded: 1) There is no difference in immunocompetence between severely and mildly jaundiced newborn infants, 2) Infection may play some role(s) in the pathogenesis of neonatal hyperbilirubinemia and 3) Determinations of total WBCs, band form granulocytes, phagocytes with Fc and C' receptors and serum IgM level are of help in the diagnosis of infection in the newborn period.
K C Hwang; K H Hsieh; J H Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology     Volume:  14     ISSN:  0253-2662     ISO Abbreviation:  Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8008067     Medline TA:  Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
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MeSH Terms
Bacterial Infections / complications
Immunoglobulins / analysis
Infant, Newborn
Jaundice, Neonatal / etiology,  immunology*
Leukocyte Count
Lymphocytes / immunology
Receptors, Complement / analysis
Receptors, Fc / analysis
Reg. No./Substance:
0/Immunoglobulins; 0/Receptors, Complement; 0/Receptors, Fc

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