Document Detail


Immunological studies in onchocercosis patients.
MedLine Citation:
PMID:  888187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunological profile of onchocercosis patients from an endemic region in Venezuela was studied. The sample was made up of patients suffering from onchocercosis and undergoing treatment, persons previously treated and apparently cured of the disease, and a group of apparently healthy individuals from the same area. The results obtained indicate that during the course of the disease the immunological apparatus suffers only slight modifications since no great variations were found in the immunoglobulin levels, the third component of the complement, the reactivity to DNCB, or the response of peripheral blood lymphocytes to mitogens. When under treatment, the levels of serum IgG and IgM are increased and there is a decrease in C3 levels. The slight modifications found can be attributed to the low severity of the disease as only one patient of those studied presented clinical manifestations ascribable to the disease (onchocercoma).
Authors:
F Merino; A Brand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tropenmedizin und Parasitologie     Volume:  28     ISSN:  0303-4208     ISO Abbreviation:  Tropenmed Parasitol     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0423216     Medline TA:  Tropenmed Parasitol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Complement C3 / analysis
Dinitrochlorobenzene / immunology
Feces / parasitology
Female
Humans
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Leukocyte Count
Lymphocyte Activation
Male
Middle Aged
Onchocerciasis / drug therapy,  immunology*
Venezuela
Chemical
Reg. No./Substance:
0/Complement C3; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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