| Immunological studies on drug-induced allergic hepatitis--hepatocellular injury by macrophage-mediated cytotoxicity. | |
| | |
MedLine Citation:
|
PMID: 6987126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
When the peripheral blood lymphocytes from patients with drug-induced allergic hepatitis were stimulated with a specific drug in vitro in the presence of a liver cytosol fraction containing liver specific antigen, lymphocyte transformation was seen in eight out of 11 patients. The macrophage activating factor (MAF), a kind of lymphokines, was also detectable in the culture medium of activated lymphocytes from seven out of eight patients who showed positive blastogenesis evaluated the uptake of 3H-glucosamine into macrophages. MAF-activated macrophages exhibited a cytotoxic effect on separated liver cells resulting in a marked inhibition of albumin synthesis. This macrophage-mediated cytotoxicity was also observed in eight out of 11 patients who showed positive lymphocyte transformation. These observations suggest that macrophage-mediated cytotoxicity may play some role in the pathogenesis of drug-induced allergic hepatitis. |
| | |
Authors:
|
Y Mizoguchi; T Shiba; F Ohnishi; T Monna; S Yamamoto; S Otani; S Morisawa |
Related Documents
:
|
8486236 - A role for cytokines as regulators of hepatic fibrogenesis. 11758836 - Modulation of heme oxygenase in tissue injury and its implication in protection against... 10440206 - Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects f... 14527086 - Cytokine-induced inflammatory liver injuries. 20508866 - Production of interleukin-17 in behcet's disease is inhibited by cyclosporin a. 8995206 - Occurrence of enzymes of free radical metabolism suggests the possible cytotoxic capaci... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Gastroenterologia Japonica Volume: 15 ISSN: 0435-1339 ISO Abbreviation: Gastroenterol. Jpn. Publication Date: 1980 |
Date Detail:
|
Created Date: 1980-05-30 Completed Date: 1980-05-30 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0152744 Medline TA: Gastroenterol Jpn Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 14-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antigens / analysis Ascitic Fluid / cytology Cytotoxicity, Immunologic* Drug Hypersensitivity / immunology* Drug-Induced Liver Injury / immunology* Female Humans Liver / immunology* Lymphocyte Activation Lymphocytes / immunology Macrophage Migration-Inhibitory Factors / analysis Macrophages / immunology* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Macrophage Migration-Inhibitory Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phenformin increases insulin binding to human cultured breast cancer cells.
Next Document: Cloning of an EcoRI-generated fragment of the leucine operon of Salmonella typhimurium.