Document Detail

Immunological studies on drug-induced allergic hepatitis--hepatocellular injury by macrophage-mediated cytotoxicity.
MedLine Citation:
PMID:  6987126     Owner:  NLM     Status:  MEDLINE    
When the peripheral blood lymphocytes from patients with drug-induced allergic hepatitis were stimulated with a specific drug in vitro in the presence of a liver cytosol fraction containing liver specific antigen, lymphocyte transformation was seen in eight out of 11 patients. The macrophage activating factor (MAF), a kind of lymphokines, was also detectable in the culture medium of activated lymphocytes from seven out of eight patients who showed positive blastogenesis evaluated the uptake of 3H-glucosamine into macrophages. MAF-activated macrophages exhibited a cytotoxic effect on separated liver cells resulting in a marked inhibition of albumin synthesis. This macrophage-mediated cytotoxicity was also observed in eight out of 11 patients who showed positive lymphocyte transformation. These observations suggest that macrophage-mediated cytotoxicity may play some role in the pathogenesis of drug-induced allergic hepatitis.
Y Mizoguchi; T Shiba; F Ohnishi; T Monna; S Yamamoto; S Otani; S Morisawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  15     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1980  
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  14-9     Citation Subset:  IM    
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MeSH Terms
Antigens / analysis
Ascitic Fluid / cytology
Cytotoxicity, Immunologic*
Drug Hypersensitivity / immunology*
Drug-Induced Liver Injury / immunology*
Liver / immunology*
Lymphocyte Activation
Lymphocytes / immunology
Macrophage Migration-Inhibitory Factors / analysis
Macrophages / immunology*
Middle Aged
Reg. No./Substance:
0/Antigens; 0/Macrophage Migration-Inhibitory Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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