Document Detail

Immunological responses after vaccination pre- and post-surgery in dogs.
MedLine Citation:
PMID:  7756420     Owner:  NLM     Status:  MEDLINE    
The effects of several commercially available vaccinations pre- and post-surgery on immune responses by monitoring the blastogenic responses of lymphocytes and humoral antibody responses in dogs were examined. Twenty clinical patients presented for surgery were studied. Canine parvovirus (CPV) serum antibody titers increased by twofold or more in 17 of 20 dogs and many dogs had an increase by day 7. In 3 of 4 dogs moderate hemagglutination inhibition (HI) titers (128 to 256) at the time of vaccination increased by twofold or more. Canine distemper virus serum antibody titers in 4 of 8 dogs with HI titers (< or = 32) at the time of vaccination had increased by twofold or more. In the blastogenic responses of lymphocytes to Concanavalin A and phytohemagglutinin, most dogs responded with a slight decrease following vaccination, but no significant change was noted. No adverse reaction caused by vaccination was noted and comparatively good production of serum antibody titers (CPV especially) was seen. Vaccination pre- and post-surgery neither induce severe immunosuppression, nor potentiate the severity of concurrent disease, and did not cause inapparent infection to become clinically apparent.
T Miyamoto; Y Taura; S Une; M Yoshitake; S Nakama; S Watanabe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  57     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
Department of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University, Japan.
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MeSH Terms
Antibody Formation / immunology*
Dogs / immunology*,  surgery
Lymphocyte Activation / immunology*
Time Factors
Vaccination / veterinary*

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