| Immunological and regulatory functions of uninfected and virus infected immature and mature subtypes of dendritic cells--a review. | |
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MedLine Citation:
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PMID: 12803463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 1868, dendritic cells (DCs) were discovered in human skin by Paul Langerhans using gold staining. These cells were named Langerhans cells (LCs) after their discoverer who, due to their dendrites, regarded them as neurons. One hundred and eleven years were to pass until it was discovered that in vertebrates these cells originate in the bone marrow as monocytes. In the 1980s, DC research was mostly carried out on DCs that are present in different tissues of mice and humans. These studies revealed that after interaction with foreign antigens, skin LCs/DCs migrate through the lymph vessels to the draining lymph nodes and induce the two arms of the immune response. The isolation of DCs from tissue cell suspensions opened the way to studies on the cells' surface proteins and their ability to stimulate immune responses. During the 1990s, studies revealed the role of DCs in the activation of naive T cells in the lymph nodes and the regulatory properties of DCs in lymph nodes, thymus, gut, and spleen. Part A of the review deals with the DC system of human and mice and immunological and regulatory functions of subsets of DCs in the skin with reference to migrating and stationary DCs, as well as the connection between DCs and the nervous system. Furthermore, the origin of both follicular DCs that are present in lymphoid tissues and thymic DCs are discussed. Part B is devoted to virus infections of DCs with an emphasis on infections caused by human herpes viruses. Part C presents the modulation of DC gene expression in response to the influenza virus. Contemporary research focuses on the role of DCs in the immune systems of vertebrates. Moreover, studies are being conducted on the regulatory functions of DCs by tissue cells in different organs of vertebrates. |
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Authors:
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Yechiel Becker |
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Publication Detail:
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Type: In Vitro; Journal Article; Review |
Journal Detail:
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Title: Virus genes Volume: 26 ISSN: 0920-8569 ISO Abbreviation: Virus Genes Publication Date: 2003 |
Date Detail:
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Created Date: 2003-06-13 Completed Date: 2003-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803967 Medline TA: Virus Genes Country: United States |
Other Details:
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Languages: eng Pagination: 119-30 Citation Subset: IM |
Affiliation:
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Department of Molecular Virology, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12272, Jerusalem 91120, Israel. becker@md.huji.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Movement Chickens Dendritic Cells / cytology, immunology*, virology* Gene Expression Herpes Simplex / immunology, pathology Herpesviridae Infections / immunology, pathology Humans Influenza, Human / genetics, immunology Lymphocyte Activation Mice T-Lymphocytes / immunology |
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