Document Detail


Immunological reclassification of 22 children with a former diagnosis of non-T, non-B ALL.
MedLine Citation:
PMID:  3319678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stored peripheral blood or bone marrow mononuclear cells from 22 pediatric patients with verified acute lymphoblastic leukemia (ALL) previously classified as non-T, non-B ALL were re-investigated by flow cytometric analysis by means of a panel of B cell-specific and -associated monoclonal antibodies (moabs) using a new analytical method described by Platz et al, the so-called Delta Channel Value method. All 22 patients were immunologically re-characterized as pre-B ALL. The reproducibility between the first (acute) and subsequent re-analysis was almost complete. 20 of the tumor cell populations could be assigned to the B cell differentiation scheme recently proposed by Nadler et al. This scheme operates with four stages of pre-B cell differentiation and each stage is defined by the expression of one to four of the following markers: HLA-DR, CD19, CD10 and CD20. Two additional markers, CD24 and CD22, were investigated in our study and allowed further subdivision of the four subgroups proposed by Nadler et al. The composition of a panel of moabs for routine classification of pre-B ALL is proposed.
Authors:
L Fugger; P Platz; L Ryder; A Svejgaard; J Heldrup; H Hertz; M Yssing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  39     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-02-20     Completed Date:  1988-02-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antibodies, Monoclonal / diagnostic use
Antigens, Neoplasm / immunology
B-Lymphocytes / immunology
Child
Child, Preschool
Female
Fluorescent Antibody Technique
Humans
Infant
Leukemia, Lymphoid / classification,  immunology*
Male
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm

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