| Immunological properties of trehalose dimycolate (cord factor) and other mycolic acid-containing glycolipids--a review. | |
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MedLine Citation:
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PMID: 11838897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mycolic acids are characteristic fatty acids of Mycobacteria and are responsible for the wax-like consistence of these microorganisms. Decades of research revealed that mycolic acid-containing glycolipids, in particular trehalose-6,6'-dimycolate (TDM, cord factor) as their best-studied representative, exert a number of immunomodifying effects. They are able to stimulate innate, early adaptive and both humoral and cellular adaptive immunity. Most functions can be associated with their ability to induce a wide range of chemokines (MCP-1, MIP-1alpha, IL-8) and cytokines (e.g., IL-12, IFN-gamma, TNF-alpha, IL-4, IL-6, IL-10). This review tries to link well-known properties of mycolic acid-containing glycolipids, e.g., stimulation of cellular and humoral immunity, granuloma formation and anti-tumor activity, with recent findings in molecular immunology and to give an outlook on potential practical applications. |
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Authors:
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R Ryll; Y Kumazawa; I Yano |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Microbiology and immunology Volume: 45 ISSN: 0385-5600 ISO Abbreviation: Microbiol. Immunol. Publication Date: 2001 |
Date Detail:
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Created Date: 2002-02-12 Completed Date: 2002-07-18 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7703966 Medline TA: Microbiol Immunol Country: Japan |
Other Details:
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Languages: eng Pagination: 801-11 Citation Subset: IM |
Affiliation:
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Japan BCG Laboratory, Kiyose, Tokyo. ryll@jet.sci.kitasato-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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pharmacology* Animals Antineoplastic Agents / immunology Cord Factors / immunology* Cytokines / biosynthesis, immunology Granuloma / immunology Humans Mice Mycobacterium tuberculosis / immunology* Neovascularization, Pathologic / immunology |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antineoplastic Agents; 0/Cord Factors; 0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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