Document Detail


Immunological properties of human decidual macrophages--a possible role in intrauterine immunity.
MedLine Citation:
PMID:  15855626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our aim was to investigate the contribution of decidual macrophages, which constitute an important immune component of the decidua in late gestation, to intrauterine defence mechanisms. Using flow cytometry we examined the ability of decidual macrophages, isolated from term decidua, to bind and phagocytose fluorescence-labelled bacterial and yeast bioparticles. We also assessed their ability to generate superoxide radicals and tumour necrosis factor-alpha following lipopolysaccharide challenge. Decidual macrophages bound bacterial and yeast particles in a dose-dependent manner, which subsequently led to phagocytosis. These macrophages also produced superoxide radicals and the pro-inflammatory cytokine TNF-alpha when challenged with bacterial lipopolysaccharides. These results suggest a role for decidual macrophages in pathogen recognition and clearance during pregnancy, and, therefore, they are likely to protect the fetus against intrauterine infections which might otherwise lead to preterm labour.
Authors:
Uma Singh; Grant Nicholson; Britta C Urban; Ian L Sargent; Uday Kishore; Andrés López Bernal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  129     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2005-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  631-7     Citation Subset:  IM    
Affiliation:
Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
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MeSH Terms
Descriptor/Qualifier:
Cell Count
Cell Culture Techniques
Decidua / immunology*
Escherichia coli
Female
Flow Cytometry
Free Radicals / metabolism
Humans
Lipopolysaccharides / pharmacology
Macrophages / immunology,  physiology*
Phagocytosis
Pregnancy / immunology*
Pregnancy Trimester, Third
Staphylococcus aureus
Stimulation, Chemical
Superoxides / metabolism
Tumor Necrosis Factor-alpha / biosynthesis
Zymosan
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 11062-77-4/Superoxides; 9010-72-4/Zymosan

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