| Immunological probes in cardiovascular disease. | |
| | |
MedLine Citation:
|
PMID: 6119995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The immune system has long been recognised as playing a central role in the organism's defence against infectious diseases and possibly the development of neoplasia. The active stimulation of the immune system by immunisation and the passive administration of antitoxins have a venerable history in medicine. Yet the concept that antibodies may be used to modify physiological or pharmacological effects or may act as diagnostic agents in the living organisms has only recently come to be recognised. Advances, both in an understanding of the structural chemistry of the antibody molecule and in the ability to culture antibody-producing cells, now permit the selection and production of homogeneous antibodies and their smaller fragments in quantity by means other than conventional immunisation. These innovations will allow the development of a new pharmacology based on the remarkable resolving power of the antibody combining site. Antibodies or their fragments are shown to inhibit the pressor action of renin, to neutralise the pharmacological actions of digitalis, to block the beta-adrenergic receptor, and to detect and image myocardial infarcts. |
| | |
Authors:
|
E Haber |
Related Documents
:
|
15993235 - Pemphigus. 21771545 - Seroprevalence of anaplasma phagocytophilum in horses in the czech republic. 22069505 - Crystal structure of the complex mab 17.2 and the c-terminal region of trypanosoma cruz... 11501885 - Periodontal diseases: to protect or not to protect is the question? 3533355 - Immunology of the placenta. 15993235 - Pemphigus. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British heart journal Volume: 47 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1982 Jan |
Date Detail:
|
Created Date: 1982-04-22 Completed Date: 1982-04-22 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1-10 Citation Subset: AIM; IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenergic beta-Antagonists / metabolism Adult Aged Antibodies* / immunology Antibody Specificity Binding, Competitive Cardiovascular Diseases / immunology* Child Child, Preschool Digitalis Glycosides / antagonists & inhibitors, poisoning Humans Immunoglobulin Fragments / immunology Infant Middle Aged Myocardial Infarction / diagnosis Myosins / immunology Renin / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Antibodies; 0/Digitalis Glycosides; 0/Immunoglobulin Fragments; EC 3.4.23.15/Renin; EC 3.6.4.1/Myosins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Operant, open-field and tonic immobility behaviours in chickens with forebrain injections of cyclohe...
Next Document: Coital blood pressure in hypertensives. Cephalgia, syncope, and the effects of beta-blockade.