Document Detail

Immunological probes in cardiovascular disease.
MedLine Citation:
PMID:  6119995     Owner:  NLM     Status:  MEDLINE    
The immune system has long been recognised as playing a central role in the organism's defence against infectious diseases and possibly the development of neoplasia. The active stimulation of the immune system by immunisation and the passive administration of antitoxins have a venerable history in medicine. Yet the concept that antibodies may be used to modify physiological or pharmacological effects or may act as diagnostic agents in the living organisms has only recently come to be recognised. Advances, both in an understanding of the structural chemistry of the antibody molecule and in the ability to culture antibody-producing cells, now permit the selection and production of homogeneous antibodies and their smaller fragments in quantity by means other than conventional immunisation. These innovations will allow the development of a new pharmacology based on the remarkable resolving power of the antibody combining site. Antibodies or their fragments are shown to inhibit the pressor action of renin, to neutralise the pharmacological actions of digitalis, to block the beta-adrenergic receptor, and to detect and image myocardial infarcts.
E Haber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  47     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  AIM; IM; S    
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MeSH Terms
Adrenergic beta-Antagonists / metabolism
Antibodies* / immunology
Antibody Specificity
Binding, Competitive
Cardiovascular Diseases / immunology*
Child, Preschool
Digitalis Glycosides / antagonists & inhibitors,  poisoning
Immunoglobulin Fragments / immunology
Middle Aged
Myocardial Infarction / diagnosis
Myosins / immunology
Renin / antagonists & inhibitors
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antibodies; 0/Digitalis Glycosides; 0/Immunoglobulin Fragments; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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