Document Detail

Immunological, physiological and pathological responses of rainbow trout (Oncorhynchus mykiss) to increasing dietary concentrations of soybean proteins.
MedLine Citation:
PMID:  10628672     Owner:  NLM     Status:  MEDLINE    
High concentrations of dietary soya were shown to suppress salmonid growth rates and non-specific immune capacity. The immunosuppression became evident at dietary inclusion rates of 60-70% and was coincident with a reduction in weight gains and the appearance of demonstrable pathological changes in the distal intestine. Further increases in soya concentrations to 80-89% caused a progressive decline in specific growth rates and exacerbation of the intestinal pathology. There was no evidence of circulating antibody responses to dietary soybean proteins at any of the rates of inclusion. These observations confirm the findings of other authors that, at concentrations of up to 20-30% inclusion in diets, soybean proteins can provide a partial replacement for fish meal, but at higher concentrations detrimental effects become apparent, not only through reduced weight gains, but also through other physiological and immunological changes.
C Burrells; P D Williams; P J Southgate; V O Crampton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  72     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  277-88     Citation Subset:  IM    
EWOS Technology Centre, Livingston, West Lothian, UK.
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MeSH Terms
Animal Feed*
Aquaculture / methods*
Cells, Cultured
Dietary Proteins / administration & dosage,  immunology*,  metabolism
Kidney / metabolism
Macrophages / metabolism
Oncorhynchus mykiss / immunology*,  physiology*
Oxygen Consumption
Reg. No./Substance:
0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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