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Immunological perspectives of leishmaniasis.
MedLine Citation:
PMID:  20606969     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Leishmania parasites have been widely used in experimental models to understand generation, maintenance and failure of immune responses underlying resistance and susceptibility to infection. The clinical outcomes of Leishmania infection depend on the infecting species and the immune status of the host. Noticeably most people exposed Leishmania never develop overt disease. Understanding the immunological events that result in failure or successful control of the parasites is fundamental to both design and evaluation of vaccines and therapies against the leishmaniases. Recent studies visualizing immune response to Leishmania major in the skin have given new insights into the different immune cells acting as hosts the parasite during different stage of infection. Control of Leishmania infection and disease progression has been associated with generation of T-helper (Th) 1 and Th2 responses respectively. Though still valid in several aspects, the Th1/Th2 paradigm is an oversimplification in need of revision. Th2 polarization has never explained severity of human leishmanial disease and a number of other T-cell subsets, including regulatory T- and Th17- cells, have important roles in susceptibility and resistance of both experimental and human leishmanial disease. This review gives an updated overview of immunological response considered to be of importance in protection, susceptibility, disease progression and cure of leishmaniasis, with a special emphasis on human diseases.
Susanne Nylén; Shalini Gautam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of global infectious diseases     Volume:  2     ISSN:  0974-8245     ISO Abbreviation:  J Glob Infect Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-07     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101521436     Medline TA:  J Glob Infect Dis     Country:  India    
Other Details:
Languages:  eng     Pagination:  135-46     Citation Subset:  -    
Department of Microbiology Tumor and Cell biology, Karolinska Institutet, Stockholm, Sweden.
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