| Immunological patterns identifying disease course and evolution in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 15949850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reliable, and easy to measure, immunological markers able to denote disease characteristics in multiple sclerosis (MS) patients are still lacking. We applied a multivariate statistical analysis on results obtained by measuring-by real-time RT-PCR-mRNA levels of 25 immunological relevant molecules in PBMCs from 198 MS patients. The combined measurement of mRNA levels of IL-1beta, TNF-alpha, TGF-beta, CCL20 and CCR3 was able to distinguish MS patients from healthy individuals. CXCR5, CCL5, and CCR3 combined mRNA levels identify primary progressive MS patients while TNF-alpha, IL-10, CXCL10 and CCR3 differentiate relapsing MS patients. Our results indicate that multi-parametric analysis of mRNA levels of immunological relevant molecules in PBMCs may represent a successful strategy for the identification of putative peripheral markers of disease state and disease activity in MS patients. |
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Authors:
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Roberto Furlan; Marco Rovaris; Filippo Martinelli Boneschi; Mohsen Khademi; Alessandra Bergami; Maira Gironi; Michela Deleidi; Federica Agosta; Diego Franciotta; Elio Scarpini; Antonio Uccelli; Mauro Zaffaroni; Asli Kurne; Giancarlo Comi; Tomas Olsson; Massimo Filippi; Gianvito Martino |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 165 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-11 Completed Date: 2005-09-08 Revised Date: 2008-05-06 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 192-200 Citation Subset: IM |
Affiliation:
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Neuroimmunology Unit, San Raffaele, Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. furlan.roberto@hsr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers Chemokine CCL20 Chemokine CCL5 Chemokines, CC / genetics, metabolism Disease Progression Female Humans Interleukin-1 / biosynthesis Linear Models Macrophage Inflammatory Proteins / genetics, metabolism Magnetic Resonance Imaging / statistics & numerical data Male Middle Aged Models, Immunological Multiple Sclerosis / diagnosis*, immunology* Multiple Sclerosis, Chronic Progressive / diagnosis, immunology Multivariate Analysis RNA, Messenger / metabolism Receptors, CCR3 Receptors, CXCR5 Receptors, Chemokine / genetics, metabolism Receptors, Cytokine / genetics, metabolism Transforming Growth Factor beta / genetics, metabolism Tumor Necrosis Factor-alpha / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CCL20 protein, human; 0/CCL5 protein, human; 0/CCR3 protein, human; 0/CXCR5 protein, human; 0/Chemokine CCL20; 0/Chemokine CCL5; 0/Chemokines, CC; 0/Interleukin-1; 0/Macrophage Inflammatory Proteins; 0/RNA, Messenger; 0/Receptors, CCR3; 0/Receptors, CXCR5; 0/Receptors, Chemokine; 0/Receptors, Cytokine; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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