Document Detail

Immunological pathways to β-cell damage in Type 1 diabetes.
MedLine Citation:
PMID:  23199020     Owner:  NLM     Status:  MEDLINE    
Following almost 30 years of intensive research, initiated by the observation that Type 1 diabetes development is associated with a characteristic pancreatic immune cell infiltrate, a picture is emerging of which of the diverse effector arms of the immune system are involved in β-cell destruction. Like any chronic pathology, there is considerable complexity, and our ability to model the disease is hampered by a lack of ready access to the target organ and limited longitudinal analyses. However, it seems that putative pathways can start to be ruled in and out, in part as a result of focused mechanistic studies that make use of new technologies, and in part through analysis of the outcomes of clinical trials of new agents aimed at halting the disease process. The picture that emerges suggests a pathway to prevention that may require combinations of therapeutic agents that target different aspects of the immune system and will need to be used with due attention to their risk-benefit profiles.
M Peakman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  30     ISSN:  1464-5491     ISO Abbreviation:  Diabet. Med.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-07-29     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Copyright Information:
© 2012 The Author. Diabetic Medicine © 2012 Diabetes UK.
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MeSH Terms
Antigens, CD4 / immunology,  metabolism*
Antigens, CD8 / immunology,  metabolism*
DNA Damage
Diabetes Mellitus, Type 1 / genetics,  immunology*,  metabolism
Disease Progression
Inflammation / genetics,  immunology*
Insulin-Secreting Cells / immunology*,  metabolism
Interleukin-10 / metabolism
Interleukin-17 / metabolism
Signal Transduction
Grant Support
MR/J006742/1//Medical Research Council; //Department of Health
Reg. No./Substance:
0/Antigens, CD4; 0/Antigens, CD8; 0/Interleukin-17; 130068-27-8/Interleukin-10

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