Document Detail


Immunological monitoring of azathioprine treatment in multiple sclerosis patients.
MedLine Citation:
PMID:  9050957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite the longstanding clinical use of azathioprine as an immunosuppressive agent in multiple sclerosis, little is known about the action of this drug on a number of parameters of putative pathogenic relevance in the disease. Eleven patients with multiple sclerosis, treated with azathioprine 2.5-3 mg/kg per day, and six untreated patients were studied with serial blood sampling for 1 year. The following immunological parameters were investigated: peripheral blood lymphocyte subsets, natural killer activity, serum IgG, IgM, ICAM-1 and tumour necrosis factor alpha (TNF-alpha). The most relevant changes included a decrease in CD3- CD56+ cells, an increase in CD4+ CD45RA+ cells and a decrease in TNF-alpha levels only in treated patients, while no changes occurred in untreated patients over a 1-year period. The decrease in TNF-alpha levels and the increase in "suppressor-inducer" lymphocytes could reduce chronic inflammation in multiple sclerosis, and paralleled an overall favourable clinical response to azathioprine treatment in our patients.
Authors:
A Salmaggi; E Corsini; L La Mantia; A Dufour; M Eoli; C Milanese; A Nespolo
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  244     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-05-29     Completed Date:  1997-05-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  167-74     Citation Subset:  IM    
Affiliation:
Instituto Nazionale Neurologico C. Besta, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Azathioprine / therapeutic use*
B-Lymphocytes / immunology
Cytokines / blood*
Drug Monitoring / methods*
Female
Humans
Immunophenotyping
Immunosuppressive Agents / therapeutic use*
Intercellular Adhesion Molecule-1 / blood
Killer Cells, Natural / immunology
Male
Multiple Sclerosis / drug therapy*,  immunology
Statistics, Nonparametric
T-Lymphocytes, Regulatory / immunology*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Immunosuppressive Agents; 126547-89-5/Intercellular Adhesion Molecule-1; 446-86-6/Azathioprine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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